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Recent Publications (2021)

Volpatti, L.R., Facklam, A.L., Cortinas, A.B., Lu, Y.C., Matranga, M.A., MacIsaac, C., Hill, M.C., Langer, R., Anderson, D.G. Microgel encapsulated nanoparticles for glucose-responsive insulin delivery. Biomaterials. 2021; Jan;267:120458. doi: 10.1016/j.biomaterials.2020.120458. Epub 2020 Nov 4. PMID: 33197650. 


Gerashchenko, M.V., Nesterchuk, M.V., Smekalova, E.M., Paulo, J.A., Kowalski, P.S., Akulich, K.A., Bogorad, R., Dmitriev, S.E., Gygi, S., Zatsepin, T., Anderson, D.G., Gladyshev, V.N., Koteliansky, V.E. Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes. Sci Rep. 2020; 10:15473. doi: 10.1038/s41598-020-72399-4. PMCID: PMC7511953. 

Krohn-Grimberghe, M., Mitchell, M.J., Schloss, M.J., Khan, O.F., Courties, G., Guimaraes, P.P.G., Rohde, D., Cremer, S., Kowalski, P.S., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S.P., Wojtkiewicz, G.R., Nayar, R., Frodermann, V., Hulsmans, M., Chung, A., Hoyer, F.F., Swirski, F.K., Langer. R., Anderson. D.G., Nahrendorf, M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020 Nov;4(11):1076-1089. doi: 10.1038/s41551-020-00623-7. Epub 2020 Oct 5.PMCID: PMC7655681.

Chu, C.K., Joseph, A.J., Limjoco, M.D., Yang, J., Bose, S., Thapa, L.S., Langer, R., Anderson, D.GChemical Tuning of Fibers Drawn from Extensible Hyaluronic Acid Networks. J Am Chem Soc. 2020 Nov 18;142(46):19715-19721. doi: 10.1021/jacs.0c09691. Epub 2020 Nov 3. PMID: 33141568

Lu, X., Miao, L., Gao, W., Chen, Z., McHugh, K.J., Sun, Y., Tochka, Z., Tomasic, S., Sadtler, K., Hyacinthe, A., Huang, Y., Graf, T., Hu, Q., Sarmadi, M., Langer, R., Anderson, D.G., Jaklenec, A. Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy. Sci Transl Med. 2020; 12(556):eaaz6606. doi: 10.1126/scitranslmed.aaz6606. PMID: 32801144.

Wei, T., Cheng, Q., Farbiak, L., Anderson, D.G., Langer. R., Siegwart, D.J. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing. ACS Nano. 2020; 14(8):9243-9262. doi: 10.1021/acsnano.0c04707. PMID: 32697075.

McAvoy, M., Doloff, J.C., Khan, O.F., Rosen, J., Langer, R., Anderson, D.G. Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury. Front Neurol. 2020; 11:644. doi: 10.3389/fneur.2020.00644. PMCID: PMC7385241.

Kawakami, R., Katsuki. S., Travers. R., Romero. D.C., Becker-Greene, D., Passos, L.S.A., Higashi, H., Blaser, M.C., Sukhova, G.K., Buttigieg, J., Kopriva, D., Schmidt, A.M., Anderson, D.G., Singh, S.A., Cardoso, L., Weinbaum, S., Libby, P., Aikawa, M., Croce, K., Aikawa, E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020; 40(8):1838-1853. doi: 10.1161/ATVBAHA.118.314087. PMCID: PMC7377960.

Miao, L., Lin. J., Huang. Y., Li. L., Delcassian. D., Ge. Y., Shi. Y., Anderson. D.G. Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver. Nat Commun. 2020; 11(1):2424. doi: 10.1038/s41467-020-16248-y. PMCID: PMC7229004.

Jiang, T., Henderson, J.M., Coote, K., Cheng, Y., Valley, H.C., Zhang, X.O., Wang, Q., Rhym, L.H., Cao, Y., Newby, G.A., Bihler, H., Mense, M., Weng, Z., Anderson, D.G., McCaffrey, A.P., Liu, D.R., Xue, W. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. Nat Commun. 2020; 11(1):1979. doi: 10.1038/s41467-020-15892-8. PMCID: PMC7181807.

Bose, S., Volpatti, L.R., Thiono, D., Yesilyurt, V., McGladrigan, C., Tang, Y., Facklam, A., Wang, A., Jhunjhunwala, S., Veiseh, O., Hollister-Lock, J., Bhattacharya, C., Weir, G.C., Greiner, D.L., Langer, R., Anderson, D.G. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nat Biomed Eng. 2020; 4(8):814-826. doi: 10.1038/s41551-020-0538-5. PMID: 32231313.

Delcassian, D., Luzhansky, I., Spanoudaki, V., Bochenek, M., McGladrigan, C., Nguyen, A., Norcross, S., Zhu, Y., Shan, C.S., Hausser, R., Shakesheff, K.M., Langer, R., Anderson, D.G. Magnetic Retrieval of Encapsulated Beta Cell Transplants from Diabetic Mice Using Dual-Function MRI Visible and Retrievable Microcapsules. Adv Mater. 2020; 32(16):e1904502. doi: 10.1002/adma.201904502. PMID: 32134138.

Leboeuf, D., Abakumova, T., Prikazchikova, T., Rhym, L, Anderson, D.G., Zatsepin, T.S, Piatkov KI. Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo. Mol Ther. 2020; 28(4):1092-1104. doi: 10.1016/j.ymthe.2020.01.021. PMCID: PMC7132617.

Reshke, R., Taylor, J.A., Savard, A., Guo, H., Rhym, L.H., Kowalski, P.S., Trung, M.T., Campbell, C., Little, W., Anderson, D.G., Gibbings, D. Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone. Nat Biomed Eng. 2020; (4):52-68. doi: 10.1038/s41551-019-0502-4. PMID: 31937944.          

Facklam, A.L., Volpatti, L.R., Anderson, D.G. Biomaterials for Personalized Cell Therapy. Adv Mater. 2020; 32(13):e1902005. doi: 10.1002/adma.201902005. Review. PMID: 31495970.

Volpatti, L.R., Matranga, M.A., Cortinas, A.B., Delcassian, D., Daniel, K.B., Langer, R., Anderson, D.G. Glucose-Responsive Nanoparticles for Rapid and Extended Self-Regulated Insulin Delivery.ACS Nano. 2020; 14(1):488-497. doi: 10.1021/acsnano.9b06395. PMID:31765558.

Smekalova, E.M., Gerashchenko, M.V., O'Connor, P.B.F., Whittaker, C.A., Kauffman, K.J., Fefilova, A.S., Zatsepin, T.S., Bogorad, R.L., Baranov, P.V., Langer, R., Gladyshev, V.N., Anderson, D.G., Koteliansky, V. In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation. Mol Ther Nucleic Acids. 2020; 19:252-266. doi: 10.1016/j.omtn.2019.11.009. PMCID: PMC6926209.

Song, C.Q., Jiang, T., Richter, M., Rhym, L.H., Koblan, L.W., Zafra, M.P., Schatoff, E.M., Doman, J.L., Cao, Y., Dow, L.E., Zhu, L.J., Anderson, D.G., Liu, D.R., Yin, H., Xue, W. Adenine base editing in an adult mouse model of tyrosinaemia. Nat Biomed Eng. 2020; 4(1):125-130. doi: 10.1038/s41551-019-0357-8. PMCID: PMC6986236.


Nakano,T., Katsuki, S., Chen, M., Decano, J.L., Halu, A., Lee, L.H., Pestana, D.V.S., Kum, A.S.T., Kuromoto, R.K., Golden, W.S., Boff, M.S., Guimaraes, G.C., Higashi, H., Kauffman, K.J., Maejima, T., Suzuki, T., Iwata, H., Barabási, A.L., Aster, J.C., Anderson, D.G., Sharma, A., Singh, S.A., Aikawa, E., Aikawa, M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588. PMCID: PMC6311723.

Patel, A.K., Kaczmarek, J.C., Bose, S., Kauffman, K.J., Mir, F., Heartlein, M.W., DeRosa, F., Langer, R., Anderson, D.G. Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium. Adv Mater. 2019; 31(8):e1805116. doi: 10.1002/adma.201805116. PMCID: PMC7490222.

Yin, H., Xue, W., Anderson, D.G. CRISPR-Cas: a tool for cancer research and therapeutics. Nat Rev Clin Oncol. 2019; 16(5):281-295. doi: 10.1038/s41571-019-0166-8. Review. PMID: 30664678.

Yu, Q., Tai, Y.Y., Tang, Y., Zhao, J., Negi, V., Culley, M.K., Pilli, J., Sun, W., Brugger, K., Mayr, J., Saggar, R., Saggar, R., Wallace, W.D., Ross, D.J., Waxman, A.B., Wendell, S.G., Mullett, S.J., Sembrat, J., Rojas, M., Khan, O.F., Dahlman, J.E., Sugahara, M., Kagiyama, N., Satoh, T., Zhang, M., Feng, N., Gorcsan, Iii. J., Vargas, S.O., Haley, K.J., Kumar, R., Graham, B.B., Langer, R., Anderson, D.G., Wang, B., Shiva, S., Bertero, T., Chan, S.Y. BOLA3 Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2019; 139(19):2238-2255. doi: 10.1161/CIRCULATIONAHA.118.035889. PMCID: PMC6519484.

Spanoudaki, V., Doloff, J.C., Huang, W., Norcross, S.R., Farah, S., Langer, R., Anderson, D.G. Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning. Proc Natl Acad Sci U S A. 2019;116 (11):4861-4870. doi: 10.1073/pnas.1815909116. PMCID: PMC6421446.

Kowalski, P.S., Rudra, A., Miao, L., Anderson, D.G. Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery. Mol Ther. 2019; 27(4): 710–728. doi: 10.1016/j.ymthe.2019.02.012. Review. PMCID:PMC6453548.

McCann, J.V., Xiao, L., Kim, D.J., Khan, O.F., Kowalski, P.S., Anderson, D.G., Pecot, C.V., Azam, S.H., Parker, J.S., Tsai, Y.S., Wolberg, A.S., Turner, S.D., Tatsumi, K., Mackman, N., Dudley, A.C. Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1. J Clin Invest. 2019;11;130:1654-1670. doi: 10.1172/JCI123106. PMCID: PMC6436861.

Wesselhoeft, R.A., Kowalski, P.S., Parker-Hale, F.C., Huang, Y., Bisaria, N., Anderson, D.G. RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo. Mol Cell. 2019; 74(3):508-520.e4. doi: 10.1016/j.molcel.2019.02.015. PMCID: PMC6724735.

Srinivasan, S., Vyas, K.,McAvoy, M., Calvaresi, P., Khan, O.F., Langer, R., Anderson, D.G., Herr, H., Polyimide Electrode-Based Electrical Stimulation Impedes Early Stage Muscle Graft Regeneration. Frontiers in Neurology. 2019; 10:252 doi: 10.3389/fneur.2019.00252. PMCID: PMC 6438882.

Dong, Y., Siegwart, D.J., Anderson, D.G. Strategies, design, and chemistry in siRNA delivery systems. Adv Drug Deliv Rev. 2019; 144:133-147. doi: 10.1016/j.addr.2019.05.004. PMID: 31102606.

Rybakova, Y., Kowalski, P.S., Huang, Y., Gonzalez, J.T., Heartlein, M.W., DeRosa, F., Delcassian, D., Anderson, D.G. mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo. Mol Ther. 2019; 27(8):1415-1423. doi: 10.1016/j.ymthe.2019.05.012. PMCID: PMC6698250.

Farah, S., Doloff, J.C., Müller, P., Sadraei, A., Han, H.J., Olafson, K., Vyas, K., Tam, H.H., Hollister-Lock, J., Kowalski, P.S., Griffin, M., Meng, A., McAvoy, M., Graham, A.C., McGarrigle, J., Oberholzer, J., Weir, G.C., Greiner, D.L., Langer, R., Anderson, D.G.Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations. Nat Mater. 2019; 18(8):892-904. doi: 10.1038/s41563-019-0377-5. PMID: 31235902.

Miao, L., Li, L., Huang, Y., Delcassian, D., Chahal, J., Han, J., Shi, Y., Sadtler, K., Gao, W., Lin, J., Doloff, J.C., Langer, R., Anderson, D.G. Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation. Nat Biotechnol. 2019; 37(10):1174-1185. doi: 10.1038/s41587-019-0247-3. PMID: 31570898.

Chen, P.Y., Qin, L., Li, G., Wang, Z., Dahlman, J.E., Malagon-Lopez, J., Gujja, S., Kauffman, K.J., Sun, L., Sun, H., Zhang, X., Aryal, B., Canfran-Duque, A., Liu, R., Kusters, P., Sehgal, A., Jiao, Y., Anderson, D.G., Gulcher, J., Fernandez-Hernando, C., Lutgens, E., Schwartz, M.A., Pober, J.S., Chittenden, T.W., Tellides, G., Simons, M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nat Metab. 2019; (9):912-926. doi: 10.1038/s42255-019-0102-3. PMCID: PMC 6767930.

McAvoy, M., Tsosie, J.K., Vyas, K.N., Khan, O.F., Sadtler, K., Langer, R., Anderson, D.G. Flexible Multielectrode Array for Skeletal Muscle Conditioning, Acetylcholine Receptor Stabilization and Epimysial Recording After Critical Peripheral Nerve Injury. Theranostics. 2019; 9(23):7099-7107. doi: 10.7150/thno.35436. PMCID: PMC 6815960.


Espinosa-Hoyos, D., Jagielska, A., Homan, K.A., Du, H., Busbee, T., Anderson, D.G., Fang, N.X., Lewis, J.A., Van Vliet, K.J. Engineered 3D-printed artificial axons. Sci Rep. 2018; 8(1):478. doi: 10.1038/s41598-017-18744-6. PMCID: PMC5765144.

Yin, H., Song, C.Q., Suresh, S., Kwan, S.Y., Wu, Q., Walsh, S., Ding, J., Bogorad, R.L., Zhu, L.J., Wolfe, S.A., Koteliansky, V., Xue, W., Langer, R., Anderson, D.G. Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nat Chem Biol. 2018; 14(3):311-316. doi: 10.1038/nchembio.2559. PMID: 29377001.

Budatha, M., Zhang, J., Zhuang, Z.W., Yun, S., Dahlman, J.E., Anderson, D.G., Schwartz, M.A. Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis. J Am Heart Assoc. 2018; 7(3). pii: e007501. doi: 10.1161/JAHA.117.007501. PMCID: PMC5850249.

Kauffman, K.J., Oberli, M.A., Dorkin, J.R., Hurtado, J.E., Kaczmarek, J.C., Bhadani, S., Wyckoff, J., Langer, R., Jaklenec, A., Anderson, D.G. Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse. Mol Ther Nucleic Acids. 2018; 10:55-63. doi: 10.1016/j.omtn.2017.11.005. PMCID: PMC5734870.

Ragelle, H., Tibbitt, M.W., Wu, S.Y., Castillo, M.A., Cheng, G.Z., Gangadharan, S.P. Anderson, D.G., Cima, M.J., Langer, R. Surface tension-assisted additive manufacturing. Nat Commun. 2018; 9(1):1184. doi: 10.1038/s41467-018-03391-w. PMCID: PMC5864961.

Capasso Palmiero, U, Kaczmarek, J.C., Fenton, O.S., Anderson, D.G. Poly(β-amino ester)-co-poly(caprolactone) Terpolymers as Nonviral Vectors for mRNA Delivery In Vitro and In Vivo. Adv Healthc Mater. 2018 May 14:e1800249. doi: 10.1002/adhm.201800249. [Epub ahead of print]. PMID: 29761648.

Espinosa-Diez, C., Wilson, R., Chatterjee, N., Hudson, C., Ruhl, R., Hipfinger, C., Helms, E., Khan, O.F., Anderson, D.G., Anand, S. MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling. Cell Death Dis. 2018; 9(6):632. doi: 10.1038/s41419-018-0690-y. PMCID: PMC5967305.

Khan, O.F., Kowalski, P.S., Doloff, J.C., Tsosie, J.K., Bakthavatchalu, V., Winn, C.B., Haupt, J., Jamiel, M., Langer, R., Anderson, D.G. Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles. Sci Adv. 2018; 4(6):eaar8409. doi: 10.1126/sciadv.aar8409. PMCID: PMC6021147.

Kowalski, P.S., Capasso Palmiero, U., Huang, Y., Rudra, A., Langer, R., Anderson, D.G. Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery. Adv Mater. 2018 Jul 5:e1801151. doi: 10.1002/adma.201801151. [Epub ahead of print]. PMCID: PMC6320729.

Wesselhoeft, R.A., Kowalski, P.S., Anderson, D.G. Engineering circular RNA for potent and stable translation in eukaryotic cells. Nat Commun. 2018; 9(1):2629. doi: 10.1038/s41467-018-05096-6. PMCID: PMC6035260.

Fenton, O.S., Kauffman, K.J., McClellan, R.L., Kaczmarek, J.C., Zeng, M.D., Andresen, J.L., Rhym, L.H., Heartlein, M.W., DeRosa, F., Anderson, D.G. Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs. Angew Chem Int Ed Engl. 2018; 57(41):13582-13586. doi: 10.1002/anie.201809056. PMID: 30112821.

Kaczmarek, J.C., Kauffman, K.J., Fenton, O.S., Sadtler, K., Patel, A.K., Heartlein, M.W., DeRosa, F., Anderson, D.G. Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells. Nano Lett. 2018; 18(10):6449-6454. doi: 10.1021/acs.nanolett.8b02917. PMCID: PMC6415675.

Meyer, I.S., Goetzke, C.C., Kespohl, M., Sauter, M., Heuser, A., Eckstein, V., Vornlocher, H.P., Anderson, D.G., Haas, J., Meder, B., Katus, H.A., Klingel, K., Beling, A., Leuschner, F. Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. Front Immunol. 2018; 9:2303. doi: 10.3389/fimmu.2018.02303. PMCID: PMC6186826.

Xie, X., Doloff, J. C., Yesilyurt, V., Sadraei, A., McGarrigle, J. J., Commis, M., Veiseh, O., Farah, S., Isa, D., Ghanis, S., Joshis, I., Vegas, A., Li, J., Wang, W. H., Bader, A., Tam, H. H., Tao, J., Chen, H. J., Yang, B. R., Williamson, K. A., Oberholzer, J., Langer, R., Anderson, D. G. Reduction of measurement noise in a contionuous glucose monitor by coating the sensor with a zwitterionic polymer. Nature Biomedical Engineering. 2018; (2) 12: 894-906. doi: 10.1038/s41551-018-0273-3. PMID: 30931173.

Aijaz, A., Li, M., Smith, D., Khong, D., LeBlon, C., Fenton, O. S., Olabisi, R. M., Libutti S., Tischfield, J., Maus, M., V., Deans, R., Barcia, R., N., Anderson, D. G., Ritz, J., Preti, R., Parekkadan, B., Biomanufacturing for clinically advanced cell therapies. Nature Biomedical Engineering. 2018; 2(6) 362-376. doi: 10.1038/s41551-018-0246-6. Review. PMID: 31011198.

Bochenek, M., A., Veiseh, O., Vegas, A. J., McGarrigle, J. J., Qi, M., Marchese, E., Omami, M., Doloff, J. C., Mendoza-Elias, J., Nourmohammadzadeh, M., Khan, A., Yeh, C. C., Xing, UY., Isa, D., Ghani, S., Li, J., Landry, C., Bader, A. R., Olejnik, K., Chen, M., Hollister-Lock, J., Wang, Y., Griener, D. L., Weir, G. C., Strand, B. L., Rokstad, A. M. A., Lacik, I., Langer, R., Anderson, D. G., Oberholzer, J. Alignate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques. Nature Biomedical Engineering. 2018; 2(11) 810-821. PMCID: PMC6413527.


Turnbull, I.C., Eltoukhy, A.A., Anderson, D.G., Costa, K.D. Lipidoid mRNA Nanoparticles for Myocardial Delivery in Rodents. Methods Mol Biol. 2017; 1521:153-166. doi: 10.1007/978-1-4939-6588-5_10. PMID: 27910047.

Schoellhammer, C.M., Lauwers, G.Y., Goettel, J.A., Oberli, M.A., Cleveland, C., Park, J.Y., Minahan, D., Chen, Y., Anderson, D.G., Jaklenec, A., Snapper, S.B., Langer, R., Traverso, G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology. 2017; 152(5):1151-1160. doi: 10.1053/j.gastro.2017.01.002. PMCID: PMC5368009.

Xie, X., Zhang, W., Abbaspourrad, A., Ahn, J., Bader, A., Bose, S., Vegas, A., Lin, J., Tao, J., Hang, T., Lee, H., Iverson, N., Bisker, G., Li, L., Strano, M.S., Weitz, D.A., Anderson, D.G. Microfluidic Fabrication of Colloidal Nanomaterials-Encapsulated Microcapsules for Biomolecular Sensing. Nano Lett. 2017; 17(3):2015-2020. doi: 10.1021/acs.nanolett.7b00026. PMID: 28152589.

Dahlman, J.E., Kauffman, K.J., Xing, Y., Shaw, T.E., Mir, F.F., Dlott, C.C., Langer, R., Anderson, D.G., Wang, E.T. Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. Proc Natl Acad Sci U S A. 2017; 114(8):2060-2065. doi: 10.1073/pnas.1620874114. PMCID: PMC5338412.

Oberli, M.A., Reichmuth, A.M., Dorkin, J.R., Mitchell, M.J., Fenton, O.S., Jaklenec, A., Anderson, D.G., Langer, R., Blankschtein, D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017; 17(3):1326-1335. doi: 10.1021/acs.nanolett.6b03329. PMCID: PMC5523404.

Yesilyurt, V., Ayoob, A.M., Appel, E.A., Borenstein, J.T., Langer, R., Anderson, D.G. Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks. Adv Mater. 2017; 29(19). doi: 10.1002/adma.201605947. PMID: 28295624.

Doloff, J.C., Veiseh, O., Vegas, A.J., Tam, H.H., Farah, S., Ma, M., Li, J., Bader, A., Chiu, A., Sadraei, A., Aresta-Dasilva, S., Griffin, M., Jhunjhunwala, S., Webber, M., Siebert, S., Tang, K., Chen, M., Langan, E., Dholokia, N., Thakrar, R., Qi, M., Oberholzer, J., Greiner, D.L., Langer, R., Anderson, D.G. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2017; 16(6):671-680. doi: 10.1038/nmat4866. PMCID: PMC5445003.

Chahal J.S., Fang, T., Woodham, A.W, Khan, O.F., Ling, J., Anderson, D.G., Ploegh, H.L. An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model. Sci Rep. 2017; 7(1):252. doi: 10.1038/s41598-017-00193-w. PMCID: PMC5427874.

Ragelle, H., Naba, A., Larson, B.L., Zhou, F., Prijić, M., Whittaker, C.A., Del Rosario, A., Langer, R., Hynes, R.O., Anderson, D.G. Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials. 2017; 128:147-159. doi: 10.1016/j.biomaterials.2017.03.008. PMID: 28327460.

Yin, H., Kauffman, K.J., Anderson, D.G. Delivery technologies for genome editing. Nat Rev Drug Discov. 2017; 16(6):387-399. doi: 10.1038/nrd.2016.280. PMID: 28337020.

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Hong, C.A., Eltoukhy, A.A., Lee, H., Langer, R., Anderson, D.G., Nam, Y.S. Dendrimeric siRNA for Efficient Gene Silencing. Angew Chem Int Ed Engl. 2015; 54(23): 6740-4. doi:10.1002/anie.201412493. PMID: 25892329.

Patel, A.K., Celiz, A.D., Rajamohan, D., Anderson, D.G., Langer, R., Davies, M.C., Alexander, M.R., Denning, C. A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays. Biomaterials. 2015; 61:257-65. doi: 10.1016/j.biomaterials.2015.05.019. PMID: 26005764.

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Mou, H., Kennedy, Z., Anderson, D.G., Yin, H., Xue, W. Precision cancer mouse models through genome editing with CRISPR-Cas9. Genome Med. 2015; 7(1):53. doi: 10.1186/s13073-015-0178-7. PMCID: PMC4460969.

Wang, D., Mou, H., Li, S., Li, Y., Hough, S., Tran, K., Li, J., Yin, H., Anderson, D.G., Sontheimer, E.J., Weng, Z., Gao, G., Xue, W. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015; 26(7):432-42. doi: 10.1089/hum.2015.087. PMCID: PMC4509492.

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Koga, J., Nakano T., Dahlman, J.E., Figueiredo, J.L., Zhang, H., Decano, J., Khan, O.F., Niida, T., Iwata, H., Aster, J.C., Yagita, H., Anderson, D.G., Ozaki, C.K., Aikawa, M. Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development: Implications for the Treatment of Vein Graft Failure. Arterioscler Thromb Vasc Biol. 2015; 35(11):2343-53. doi: 10.1161/ATVBAHA.115.305516. PMID: 26404485.

Webber, M.J., Anderson, D.G. Smart approaches to glucose-responsive drug delivery. J Drug Target. 2015; 23(7-8):651-5. doi: 10.3109/1061186X.2015.1055749. PMID: 26453161.

Kauffman, K.J., Dorkin, J.R., Yang, J.H., Heartlein, M.W., DeRosa, F., Mir, F.F., Fenton, O.S., Anderson, D.G. Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs. Nano Lett. 2015; 15(11):7300-6. doi: 10.1021/acs.nanolett.5b02497. PMID: 26469188.

Schoellhammer, C.M., Schroeder, A., Maa, R., Lauwers, G.Y., Swiston, A., Zervas, M., Barman, R., DiCiccio, A.M., Brugge, W.R., Anderson, D.G., Blankschtein, D., Langer, R., Traverso, G. Ultrasound-mediated gastrointestinal drug delivery. Sci Transl Med. 2015; 7(310):310ra168. doi: 10.1126/scitranslmed.aaa5937. PMID: 26491078.

Kauffman, K.J., Webber, M.J., Anderson, D.G. Materials for Non-viral intracellular delivery of messenger RNA therapeutics. J Control Release. 2015; pii: S0168-3659(15)30283-2. doi: 10.1016/j.jconrel.2015.12.032. PMID: 26718856.

Appel, E.A., Tibbitt, M.W., Greer, J.M., Fenton, O.S., Kreuls, K., Anderson, D.G., Langer, R. Exploiting Electrostatic Interactions in Polymer-Nanoparticle Hydrogels. ACS Macro Letters. 2015; 4 (8):848-852. doi:10.1021/acsmacrolett.5b00416.


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Eltoukhy, A.A., Chen, D., Veiseh, O., Pelet, J.M., Yin, H., Dong, Y., Anderson, D.G. Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles. Biomaterials. 2014; 35(24):6454-61. doi: 10.1016/j.biomaterials.2014.04.014. PMID: 24831975.

Speicher, T., Siegenthaler, B., Bogorad, R.L., Ruppert, R., Petzold, T., Padrissa-Altes, S., Bachofner, M., Anderson, D.G., Koteliansky, V., Fassler, R., Werner, S. Knockdown and knockout of beta1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling. Nat Commun. 2014; 5:3862. doi: 10.1038/ncomms4862. PMID: 24844558.

Bogorad, R.L., Yin, H., Zeigerer, A., Nonaka, H., Ruda, V.M., Zerial, M., Anderson, D.G., Koteliansky, V. Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. Nat Commun. 2014; 5:3869. doi: 10.1038/ncomms4869. PMCID: PMC4107318.

Celiz, A.D., Smith, J.G., Langer, R., Anderson, D.G., Winkler, D.A., Barrett, D.A., Davies, M.C., Young, L.E., Denning, C., Alexander, M.R. Materials for stem cell factories of the future. Nat Mater. 2014; 13(6):570-9. doi: 10.1038/nmat3972. PMID: 24845996.

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Algahtani, M.S., Scurr, D.J., Hook, A.L., Anderson, D.G., Langer, R.S., Burley, J.C., Alexander, M.R., Davies, M.C. High throughput screening for biomaterials discovery. Journal of Controlled Release. 2014; 190:115-26. doi: 10.1016/j.jconrel.2014.06.045. PMID: 24993427.

Eltoukhy, A.A., Sahay, G., Cunningham, J.M., Anderson, D.G. Niemann-pick c1 affects the gene delivery efficacy of degradable polymeric nanoparticles. ACS Nano. 2014; 8(8):7905-13. doi: 10.1021/nn501630h. PMCID: PMC4148171.

Yin, H., Kanasty, R.L., Eltoukhy, A.A., Vegas, A.J., Dorkin, J.R., Anderson, D.G. Non-viral vectors for gene-based therapy. Nature Reviews Genetics. 2014; 15(8):541-55. doi: 10.1038/nrg3763. PMID: 25022906.

Xue, W., Dahlman, J.E., Tammela ,T., Khan, O.F., Sood, S., Dave, A., Cai, W., Chirino, L.M., Yang, G.R., Bronson, R., Crowley, D.G., Sahay, G., Schroeder, A., Langer, R., Anderson, D.G., Jacks, T. Small RNA combination therapy for lung cancer. Proc Natl Acad Sci U S A. 2014; 111(34):E3553-61. doi: 10.1073/pnas.1412686111. PMCID: PMC4151750.

Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N.S., Cai, W., Yang, G., Bronson, R., Crowley, D.G., Zhang, F., Anderson, D.G., Sharp, P.A., Jacks, T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 2014; 514(7522):380-4. doi: 10.1038/nature13589. PMCID: PMC4199937.

Chang, T.Y., Shi, P., Steinmeyer, J.D., Chatnuntawech, I., Tillberg, P., Love, K.T., Eimon, P.M., Anderson, D.G., Yanik, M.F. Organ-targeted high-throughput in vivo biologics screen identifies materials for RNA delivery. Integrative Biology. 2014; 6(10):926-34. doi: 10.1039/c4ib00150h. PMID: 25184623. PMCID: PMC4350364.

Yin, H., Xue, W., Chen, S., Bogorad, R.L., Benedetti, E., Grompe, M., Koteliansky, V., Sharp, P.A., Jacks, T., Anderson, D.G. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat Biotechnol. 2014; 32(6):551-53. doi: 10.1038/nbt.2884. PMCID: PMC4157757.

Traverso, G., Schoellhammer, C.M., Schroeder, A., Maa, R., Lauwers, G.Y., Polat, B.E., Anderson, D.G., Blankschtein, D., Langer, R. Microneedles for Drug Delivery via the Gastrointestinal Tract. J Pharm Sci. 2014; 104(2):362-7. doi: 10.1002/jps.24182. PMCID: PMC4349565.

Khan, O. F., Zaia, E. W., Yin, H., Bogorad, R. L., Pelet, J. M., Webber, M. J., Zhuang, I., Dahlman, J. E., Langer, R. and Anderson, D. G. (2014), Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo. Angew. Chem. Int. Ed. 2014; 53: 14397–14401. doi: 10.1002/anie.20140822. PMID: 25354018.

Sanni, O., Chang, C.-Y., Anderson, D. G., Langer, R., Davies, M. C., Williams, P. M., Williams, P., Alexander, M. R. and Hook, A. L. Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity. Advanced Healthcare Materials. 2014; doi: 10.1002/adhm.201400648. PMCID: PMC4409840.

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Ishikawa, K., Fish, K., Aguero, J., Yaniz-Galende, E., Jeong, D., Kho, C., Tilemann, L., Fish, L., Liang, L., Eltoukhy, A.A., Anderson, D.G., Zsebo, K., Costa, K., Hajjar, R. J. Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine. Circulation: Heart Failure. 2014; doi:10.1161/CIRCHEARTFAILURE.114.001711. PMCID: PMC4303518.

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Peng, W., Dunton, C., Holtz, D., Parva, M., Stampler, K., Forwood, M., Gogoi, R., Lace, M.J., Anderson, D.G., Sawicki, J.A. DNA nanotherapy for pre-neoplastic cervical lesions. Gynecol Oncol. 2013; 128(1):101-6. doi: 10.1016/j.ygyno.2012.10.018. PMID: 23103931.

Alabi, C.A., Sahay, G., Langer, R., Anderson, D.G. Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles. Integrative Biology. 2013; 5(1):224-30. doi: 10.1039/c2ib20155k. PMCID: PMC3524365.

Heller, D.A., Levi, Y., Pelet, J.M., Doloff, J.C., Wallas, J., Pratt, G.W., Jiang, S., Sahay, G., Schroeder, A., Schroeder, J.E., Chyan, Y., Zurenko, C., Querbes, W., Manzano, M., Kohane, D.S., Langer, R., Anderson, D.G. Modular 'click-in-emulsion' bone-targeted nanogels. Advanced Materials. 2013; 25(10):1449-54. doi: 10.1002/adma.201202881. PMCID: PMC3815631.

Ma, M., Chiu, A., Sahay, G., Doloff, J.C., Dholakia, N., Thakrar, R., Cohen, J., Vegas, A., Chen, D., Bratlie, K.M., Dang, T., York, R.L., Hollister-Lock, J., Weir, G.C., Anderson, D.G. Core-shell hydrogel microcapsules for improved islets encapsulation. Adv Healthc Mater. 2013; 2(5):667-72. doi: 10.1002/adhm.201200341. PMCID: PMC3814167.

Eltoukhy, A.A., Chen, D., Alabi, C.A., Langer, R., Anderson, D.G. Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability. Advanced Materials. 2013; 25(10):1487-93. doi: 10.1002/adma.201204346. PMCID: PMC3824380.

Ma, M., Guo, L., Anderson, D.G., Langer, R. Bio-inspired polymer composite actuator and generator driven by water gradients. Science. 2013; 339(6116):186-9. doi: 10.1126/science.1230262. PMCID: PMC3635810.

Sharei, A., Zoldan, J., Adamo, A., Sim, W.Y., Cho, N., Jackson, E., Mao, S., Schneider, S., Han, M.J., Lytton-Jean, A., Basto, P.A., Jhunjhunwala, S., Lee, J., Heller, D.A., Kang, J.W., Hartoularos, G.C., Kim, K.S., Anderson, D.G., Langer, R., Jensen, K.F. A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A. 2013; 110(6):2082-7. doi: 10.1073/pnas.1218705110. PMCID: PMC3568376.

Hook, A.L., Scurr, D.J., Anderson, D.G., Langer, R., Williams, P., Davies, M., Alexander, M. High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis. 2013; 45(1):181-4. doi: 10.1002/sia.4910. PMCID: PMC3579490.

Celiz, A.D., Hook, A.L., Scurr, D.J., Anderson, D.G., Langer, R., Davies, M.C., Alexander, M.R. ToF-SIMS imaging of a polymer microarray prepared using ink-jet printing of acrylate monomers. Surface and Interface Analysis. 2013; 45(1):202-5. doi: 10.1002/sia.5042.

Scurr, D.J., Hook, A.L., Burley, J.A., Williams, P.M., Anderson, D.G., Langer, R.C., Davies, M.C., Alexander, M.R. Strategies for MCR image analysis of large hyperspectral data-sets. Surface and Interface Analysis. 2013; 45(1):466-70. doi: 10.1002/sia.5040. PMCID: PMC3579489.

Hook, A.L., Scurr, D.J., Burley, J.C., Langer, R., Anderson, D.G., Davies, M.C., Alexander, M.R. Analysis and prediction of defects in UV photo-initiated polymer microarrays. Journal of Materials Chemistry B. 2013; 1(7):1035-43. doi: 10.1039/C2TB00379A. PMCID: PMC4357255.

Haq, R., Yokoyama, S., Hawryluk, E.B., Jonsson, G.B., Frederick, D.T., McHenry, K., Porter, D., Tran, T.N., Love, K.T., Langer, R., Anderson, D.G., Garraway, L.A., Duncan, L.M., Morton, D.L., Hoon, D.S., Wargo, J.A., Song, J.S., Fisher, D.E. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci U S A. 2013; 110(11):4321-6. doi: 10.1073/pnas.1205575110. PMCID: PMC3600451.

Jiang, S., Eltoukhy, A.A., Love, K.T., Langer, R., Anderson, D.G. Lipidoid-coated iron oxide nanoparticles for efficient DNA and siRNA delivery. Nano Lett. 2013; 13(3):1059-64. doi: 10.1021/nl304287a. PMCID: PMC3992974.

Majmudar, M.D., Yoo, J., Keliher, E.J., Truelove, J.J., Iwamoto, Y., Sena, B., The Journal of Experimental Medicine, P., Borodovsky, A., Fitzgerald, K., Di Carli, M.F., Libby, P., Anderson, D.G., Swirski, F.K., Weissleder, R., Nahrendorf, M. Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circ Res. 2013; 112(5):755-61. doi: 10.1161/CIRCRESAHA.111.300576. PMCID: PMC3586287.

Hook, A.L., Chang, C.Y., Yang, J., Atkinson, S., Langer, R., Anderson, D.G., Davies, M.C., Williams, P., Alexander, M.R. Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials. 2013; 25(18):2542-7. doi: 10.1002/adma.201204936. PMCID: PMC3736217.

Gu, Z., Aimetti, A.A., Wang, Q., Dang, T.T., Zhang, Y., Veiseh, O., Cheng, H., Langer, R.S., Anderson, D.G. Injectable nano-network for glucose-mediated insulin delivery. ACS Nano. 2013; 7(5):4194-201. doi: 10.1021/nn400630x. PMCID: PMC4107450.

Mizrahi, B., Shankarappa, S.A., Hickey, J.M., Dohlman, J.C., Timko, B.P., Whitehead, K.A., Lee, J.J., Langer, R., Anderson, D.G., Kohane, D.S. A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013; 23(12):1527-33. doi: 10.1002/adfm.201202433. PMCID: PMC3646576.

Alabi, C.A., Love, K.T., Sahay, G., Yin, H., Luly, K.M., Langer, R., Anderson, D.G. Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery. Proc Natl Acad Sci U S A. 2013; 110(32):12881-6. doi: 10.1073/pnas.1306529110. PMCID: PMC3740846.

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Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., Buganim, Y., Schroeder, A., Langer, R., Anderson, D.G. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013; 31(7):653-8. doi: 10.1038/nbt.2614. PMCID: PMC3814166.

Dang, T.T., Thai, A.V., Cohen, J., Slosberg, J.E., Siniakowicz, K., Doloff, J.C., Ma, M., Hollister-Lock, J., Tang, K.M., Gu, Z., Cheng, H., Weir, G.C., Langer, R., Anderson, D.G. Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug. Biomaterials. 2013; 34(23):5792-801. doi: 10.1016/j.biomaterials.2013.04.016. PMCID: PMC3901568.

Majmudar, M.D., Keliher, E.J., Heidt, T., Leuschner, F., Truelove, J., Sena, B. The Journal of Experimental Medicineorbatov, R., Iwamoto, Y., Dutta, P., Wojtkiewicz, G., Courties, G., Sebas, M., Borodovsky, A., Fitzgerald, K., Nolte, M.W., Dickneite, G., Chen, J.W., Anderson, D.G., Swirski, F.K., Weissleder, R., Nahrendorf, M. Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation. 2013; 127(20):2038-46. doi: 10.1161/CIRCULATIONAHA.112.000116. PMCID: PMC3661714.

Zhang, Y., Pelet, J.M., Heller, D.A., Dong, Y., Chen, D., Gu, Z., Joseph, B.J., Wallas, J., Anderson, D.G. Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery. Advanced Materials. 2013; 25(33):4641-5. doi: 10.1002/adma.201301917. PMCID: PMC3898629.

Zugates, G.T., Anderson, D.G., Langer, R. High-throughput methods for screening polymeric transfection reagents. Cold Spring Harb Protoc. 2013; 2013(11). doi: 10.1101/pdb.prot078634. PMID: 24184768.

Karagiannis, E.D., Urbanska, A.M., Sahay, G., Pelet, J.M., Jhunjhunwala, S., Langer, R., Anderson, D.G. Rational design of a biomimetic cell penetrating peptide library. ACS Nano. 2013; 7(10):8616-26. doi: 10.1021/nn4027382. PMCID: PMC3898733.

Li, W., Lee, S., Ma, M., Kim, S.M., Guye, P., Pancoast, J.R., Anderson, D.G., Weiss, R., Lee, R.T., Hammond, P.T. Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic beta-cells. Sci Rep. 2013; 3:2863. doi: 10.1038/srep02863. PMCID: PMC3790197.

Gu, Z., Dang, T.T., Ma, M., Tang, B.C., Cheng, H., Jiang, S., Dong, Y., Zhang, Y., Anderson, D.G. Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery. ACS Nano. 2013; 7(8):6758-66. doi: 10.1021/nn401617u. PMID: 23834678.

Kanasty, R., Dorkin, J.R., Vegas, A., Anderson, D. Delivery materials for siRNA therapeutics. Nat Mater. 2013; 12(11):967-77. doi: 10.1038/nmat3765. PMID: 24150415.


Novobrantseva, T.I., Borodovsky, A., Wong, J., Klebanov, B., Zafari, M., Yucius, K., Querbes, W., Ge, P., Ruda, V.M., Milstein, S., Speciner, L., Duncan, R., Barros, S., Basha, G., Cullis, P., Akinc, A., Donahoe, J.S., Narayanannair Jayaprakash, K., Jayaraman, M., Bogorad, R.L., Love, K., Whitehead, K., Levins, C., Manoharan, M., Swirski, F.K., Weissleder, R., Langer, R., Anderson, D.G., de Fougerolles, A., Nahrendorf, M., Koteliansky, V. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Molecular Therapy Nucleic Acids. 2012; 1:e4. doi: 10.1038/mtna.2011.3. PMCID: PMC3381593.

Schroeder, A., Heller, D.A., Winslow, M.M., Dahlman, J.E., Pratt, G.W., Langer, R., Jacks, T., Anderson, D.G. Treating metastatic cancer with nanotechnology. Nature Reviews Cancer. 2012; 12(1):39-50. doi: 10.1038/nrc3180. PMID: 22193407.

Schroeder, A., Dahlman, J.E., Sahay, G., Love, K.T., Jiang, S., Eltoukhy, A.A., Levins, C.G., Wang, Y., Anderson, D.G. Alkane-modified short polyethyleneimine for siRNA delivery. Journal of Controlled Release. 2012; 160(2):172-6. doi: 10.1016/j.jconrel.2011.11.030. PMCID: PMC3814168.

Sun, S., Wang, M., Knupp, S.A., Soto-Feliciano, Y., Hu., X, Kaplan, D.L., Langer, R., Anderson, D.G., Xu, Q. Combinatorial library of lipidoids for in vitro DNA delivery. Bioconjugate Chemistry. 2012; 23(1):135-40. doi: 10.1021/bc200572w. PMCID: PMC3261308.

Hook, A.L., Chang, C.Y., Yang, J., Scurr, D.J., Langer, R., Anderson, D.G., Atkinson, S., Williams, P., Davies, M.C., Alexander, M.R. Polymer microarrays for high throughput discovery of biomaterials. Journal of Visualized Experiments. 2012; (59):e3636. doi: 10.3791/3636. PMCID: PMC3462568.

Cortez-Retamozo, V., Etzrodt, M., Newton, A., Rauch, P.J., Chudnovskiy, A., Berger, C., Ryan, R.J., Iwamoto, Y., Marinelli, B., Gorbatov, R., Forghani, R., Novobrantseva, T.I., Koteliansky, V., Figueiredo, J.L., Chen, J.W., Anderson, D.G., Nahrendorf, M., Swirski, F.K., Weissleder, R., Pittet, M.J. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012; 109(7):2491-6. doi: 10.1073/pnas.1113744109. PMCID: PMC3289379.

Kanasty, R.L., Whitehead, K.A., Vegas, A.J., Anderson, D.G. Action and reaction: the biological response to siRNA and its delivery vehicles. Molecular Therapy. 2012; 20(3):513-24. doi: 10.1038/mt.2011.294. PMCID: PMC3293611.

Siegwart, D.J., Leiendecker, M., Langer, R., Anderson, D.G. Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers. Macromolecules. 2012; 45(3):1254-61. doi: 10.1021/ma3000219. PMCID: PMC3627424.

Eltoukhy, A.A., Siegwart, D.J., Alabi, C.A., Rajan, J.S., Langer, R., Anderson, D.G. Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity. Biomaterials. 2012; 33(13):3594-603. doi: 10.1016/j.biomaterials.2012.01.046. PMCID: PMC3326358.

Nguyen, D.N., Mahon, K.P., Chikh, G., Kim, P., Chung, H., Vicari, A.P., Love, K.T., Goldberg, M., Chen, S., Krieg, A.M., Chen, J., Langer, R., Anderson, D.G. Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Proc Natl Acad Sci U S A. 2012; 109(14):E797-803. doi: 10.1073/pnas.1121423109. PMCID: PMC3325698.

Urbanska, A.M., Karagiannis, E.D., Guajardo, G., Langer, R.S., Anderson, D.G. Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer. Biomaterials. 2012; 33(18):4752-61. doi: 10.1016/j.biomaterials.2012.03.023. PMCID: PMC3586541.

Cho, S.W., Yang, F., Son, S.M., Park, H.J., Green, J.J., Bogatyrev, S., Mei, Y., Park, S., Langer, R., Anderson, D.G. Therapeutic angiogenesis using genetically engineered human endothelial cells. Journal of Controlled Release 2012; 160(3):515-24. doi: 10.1016/j.jconrel.2012.03.006. PMCID: PMC3372613.

Fisher, O.Z., Larson, B.L., Hill, P.S., Graupner, D., Nguyen-Kim, M.T., Kehr, N.S., De Cola, L., Langer, R., Anderson, D.G. Melanin-like hydrogels derived from gallic macromers. Advanced Materials. 2012; 24(22):3032-6. doi: 10.1002/adma.201104437. PMID: 22566290.

Lee, H., Lytton-Jean, A.K., Chen, Y., Love, K.T., Park, A.I., Karagiannis, E.D., Sehgal, A., Querbes, W., Zurenko, C.S., Jayaraman, M., Peng, C.G., Charisse, K., Borodovsky, A., Manoharan, M., Donahoe, J.S., Truelove, J., Nahrendorf, M., Langer, R., Anderson, D.G. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nature Nanotechnology. 2012; 7(6):389-93. doi: 10.1038/nnano.2012.73. PMCID: PMC3898745.

Chen, D., Love, K.T., Chen, Y., Eltoukhy, A.A., Kastrup, C., Sahay, G., Jeon, A., Dong, Y., Whitehead, K.A., Anderson, D.G. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. Journal of the American Chemical Society. 2012; 134(16):6948-51. doi: 10.1021/ja301621z. PMID: 22475086.

Kang, S.M., Hwang, N.S., Yeom, J., Park, S.Y., Messersmith, P.B., Choi, I.S., Langer, R., Anderson, D.G., Lee, H. One-Step Multipurpose Surface Functionalization by Adhesive Catecholamine. Advanced Functional Materials. 2012; 22(14):2949-55. doi: 10.1002/adfm.201200177. PMCID: PMC3619432.

Vacanti, N.M., Cheng, H., Hill, P.S., Guerreiro, J.D., Dang, T.T., Ma, M., Watson, S., Hwang, N.S., Langer, R., Anderson, D.G. Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response. Biomacromolecules. 2012; 13(10):3031-8. doi: 10.1021/bm300520u. PMCID: PMC3466020.

Weldon, C.B., Tsui, J.H., Shankarappa, S.A., Nguyen, V.T., Ma, M., Anderson, D.G., Kohane, D.S. Electrospun drug-eluting sutures for local anesthesia. Journal of Controlled Release. 2012; 161(3):903-9. doi: 10.1016/j.jconrel.2012.05.021. PMCID: PMC3412890.

Whitehead, K.A., Matthews, J., Chang, P.H., Niroui, F., Dorkin, J.R., Severgnini, M., Anderson, D.G. In vitro-in vivo translation of lipid nanoparticles for hepatocellular siRNA delivery. ACS Nano. 2012; 6(8):6922-9. doi: 10.1021/nn301922x. PMCID: PMC3429655.

Alabi, C.A., Love, K.T., Sahay, G., Stutzman, T., Young, W.T., Langer, R., Anderson, D.G. FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes. ACS Nano. 2012; 6(7):6133-41. doi: 10.1021/nn3013838. PMCID: PMC3404193.

Cheng, H., Byrska-Bishop, M., Zhang, C.T., Kastrup, C.J., Hwang, N.S., Tai, A.K., Lee, W.W., Xu, X., Nahrendorf, M., Langer, R., Anderson, D.G. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. Biomaterials. 2012; 33(20):5004-12. doi: 10.1016/j.biomaterials.2012.03.065. PMCID: PMC3366278.

Schroeder, A., Goldberg, M.S., Kastrup, C., Wang, Y., Jiang, S., Joseph, B.J., Levins, C.G., Kannan, S.T., Langer, R., Anderson, D.G. Remotely activated protein-producing nanoparticles. Nano Letters. 2012; 12(6):2685-9. doi: 10.1021/nl2036047. PMCID: PMC3388722.

Li, J., Song, J.S., Bell, R.J., Tran, T.N., Haq, R., Liu, H., Love, K.T., Langer, R., Anderson, D.G., Larue, L., Fisher, D.E. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012; 8(5):e1002688. doi: 10.1371/journal.pgen.1002688. PMCID: PMC3342948.

Karagiannis, E.D., Alabi, C.A., Anderson, D.G. Rationally designed tumor-penetrating nanocomplexes. ACS Nano. 2012; 6(10):8484-7. doi: 10.1021/nn304707b. PMID: 23088785.

Chen, P.Y., Qin, L., Barnes, C., Charisse, K., Yi, T., Zhang, X., Ali, R., Medina, P.P., Yu, J., Slack, F.J., Anderson, D.G., Kotelianski, V., Wang, F., Tellides, G., Simons, M. FGF regulates TGF-beta signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012; 2(6):1684-96. doi: 10.1016/j.celrep.2012.10.021. PMCID: PMC3534912.

Bratlie, K.M., York, R.L., Invernale, M.A, Langer, R., Anderson, D.G. Materials for diabetes therapeutics. Adv Healthc Mater. 2012; 1(3):267-84. doi: 10.1002/adhm.201200037. PMCID: PMC3899887.

Hook, A.L., Chang, C.Y., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D.J., Langer, R., Anderson, D.G., Williams, P., Davies, M.C., Alexander, M.R. Combinatorial discovery of polymers resistant to bacterial attachment. Nat Biotechnol. 2012; 30(9):868-75. doi: 10.1038/nbt.2316. PMCID: PMC3796337.

Epa, V.C., Yang, J., Mei, Y., Hook, A.L., Langer, R., Anderson, D.G., Davies, M.C., Alexander, M.R., Winkler, D.A. Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry. 2012; 22(39):20902-6. doi: 10.1039/C2JM34782B. PMCID: PMC3787298.

Kastrup, C.J., Nahrendorf, M., Figueiredo, J.L., Lee, H., Kambhampati, S., Lee, T., Cho, S.W., Gorbatov, R., Iwamoto, Y., Dang, T.T., Dutta, P., Yeon, J.H., Cheng, H., Pritchard, C.D., Vegas, A.J., Siegel, C.D., MacDougall, S., Okonkwo, M., Thai, A., Stone, J.R., Coury, A.J., Weissleder, R., Langer, R., Anderson, D.G. Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proc Natl Acad Sci U S A. 2012; 109(52):21444-9. doi: 10.1073/pnas.1217972110. PMCID: PMC3535589.


Zoldan, J., Karagiannis, E.D., Lee, C.Y., Anderson, D.G., Langer, R., Levenberg, S. The influence of scaffold elasticity on germ layer specification of human embryonic stem cells. Biomaterials. 2011; 32(36):9612-21. doi: 10.1016/j.biomaterials.2011.09.012. PMCID: PMC3313669.

Siegwart, D.J., Whitehead, K.A., Nuhn, L., Sahay, G., Cheng, H., Jiang, S., Ma, M., Lytton-Jean, A., Vegas, A., Fenton, P., Levins, C.G., Love, K.T., Lee, H., Cortez, C., Collins, S.P., Li, Y.F., Jang, J., Querbes, W., Zurenko, C., Novobrantseva, T., Langer, R., Anderson, D.G. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. Proc Natl Acad Sci U S A. 2011; 108(32):12996-3001. doi: 10.1073/pnas.1106379108. PMCID: PMC3156157.

Chung, H.J., Lee, H., Bae, K.H., Lee, Y., Park, J., Cho, S.W., Hwang, J.Y., Park, H., Langer, R., Anderson, D., Park, T.G. Facile synthetic route for surface-functionalized magnetic nanoparticles: cell labeling and magnetic resonance imaging studies. ACS Nano. 2011; 5(6):4329-36. doi: 10.1021/nn201198f. PMCID: PMC4060805.

Pritchard, C.D., O'Shea, T.M., Siegwart, D.J., Calo, E., Anderson, D.G., Reynolds, F.M., Thomas, J.A., Slotkin, J.R., Woodard, E.J., Langer, R. An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Biomaterials. 2011; 32(2):587-97. doi: 10.1016/j.biomaterials.2010.08.106. PMCID: PMC4070531.

Whitehead, K.A., Sahay, G., Li, G.Z., Love, K.T., Alabi, C.A., Ma, M., Zurenko, C., Querbes, W., Langer, R.S., Anderson, D.G. Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery. Molecular Therapy. 2011; 19(9):1688-94. doi: 10.1038/mt.2011.141. PMCID: PMC3182356.

Zhou, M., Liu, H., Venkiteshwaran, A., Kilduff, J., Anderson, D.G., Langer, R., Belfort, G. High throughput discovery of new fouling-resistant surfaces. Journal of Materials Chemistry. 2011; 21(3):693-704. doi: 10.1039/C0JM01266A. PMCID: PMC5308054.

Liu, W.F., Ma, M., Bratlie, K.M., Dang, T.T., Langer, R., Anderson, D.G. Real-time in vivo detection of biomaterial-induced reactive oxygen species. Biomaterials. 2011; 32(7):1796-801. doi: 10.1016/j.biomaterials.2010.11.029. PMCID: PMC4130482.

Dang, T.T., Bratlie, K.M., Bogatyrev, S.R., Chen, X.Y., Langer, R., Anderson, D.G. Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response. Biomaterials. 2011; 32(19):4464-70. doi: 10.1016/j.biomaterials.2011.02.048. PMCID: PMC5279724.

Ma, M., Liu, W.F., Hill, P.S., Bratlie, K.M., Siegwart, D.J., Chin, J., Park, M., Guerreiro, J., Anderson, D.G. Development of cationic polymer coatings to regulate foreign-body responses. Advanced Materials. 2011; 23(24):H189-94. doi: 10.1002/adma.201100513. PMCID: PMC3957182.

Lytton-Jean, A.K., Langer, R., Anderson, D.G. Five years of siRNA delivery: spotlight on gold nanoparticles. Small. 2011; 7(14):1932-7. doi: 10.1002/smll.201100761. PMID: 21681985.

Saha, K., Mei, Y., Reisterer, C.M., Pyzocha, N.K., Yang, J., Muffat, J., Davies, M.C., Alexander, M.R., Langer, R., Anderson, D.G., Jaenisch, R. Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A. 2011; 108(46):18714-9. doi: 10.1073/pnas.1114854108. PMCID: PMC3219112.

Hook, A.L., Yang, J., Chen, X., Roberts, C.J., Mei, Y., Anderson, D.G., Langer, R., Alexander, M.R., Davies, M.C. Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray. Soft Matter. 2011; 7(16):7194-7. doi: 10.1039/C1SM06063E. PMCID: PMC3524802.

Whitehead. K.A., Dahlman, J.E., Langer, R.S., Anderson, D.G. Silencing or stimulation? siRNA delivery and the immune system. Annu Rev Chem Biomol Eng. 2011; 2:77-96. doi: 10.1146/annurev-chembioeng-061010-114133. PMID: 22432611.

Flessner, R.M., Jewell, C.M., Anderson, D.G., Lynn, D.M. Degradable polyelectrolyte multilayers that promote the release of siRNA. Langmuir. 2011; 27(12):7868-76. doi: 10.1021/la200815t. PMCID: PMC3115451.

Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T.I., Donahoe, J.S., Courties, G., Lee, K.M., Kim, J.I., Markmann, J.F., Marinelli, B., Panizzi, P., Lee, W.W., Iwamoto, Y., Milstein, S., Epstein-Barash, H., Cantley, W., Wong, J., Cortez-Retamozo, V., Newton, A., Love, K., Libby, P., Pittet, M.J., Swirski, F.K., Koteliansky, V., Langer, R., Weissleder, R., Anderson, D.G., Nahrendorf, M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nature Biotechnology. 2011; 29(11):1005-10. doi: 10.1038/nbt.1989. PMCID: PMC3212614.

Hwang, N.S., Im, S.G., Wu, P.B., Bichara, D.A., Zhao, X., Randolph, M.A., Langer, R., Anderson, D.G. Chondrogenic priming adipose-mesenchymal stem cells for cartilage tissue regeneration. Pharmaceutical Research. 2011; 28(6):1395-405. doi: 10.1007/s11095-011-0445-2. PMID: 21494923.

Zoldan, J., Lytton-Jean, A.K., Karagiannis, E.D., Deiorio-Haggar, K., Bellan, L.M., Langer, R., Anderson, D.G. Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture. Biomaterials. 2011; 32(31):7793-800. doi: 10.1016/j.biomaterials.2011.06.057. PMCID: PMC3313656.

Dvir, T., Bauer, M., Schroeder, A., Tsui, J.H., Anderson, D.G., Langer, R., Liao, R., Kohane, D.S. Nanoparticles targeting the infarcted heart. Nano Letters. 2011; 11(10):4411-4. doi: 10.1021/nl2025882. PMCID: PMC3192253.

Vuorimaa, E., Ketola, T.M., Green, J.J., Hanzlikova, M., Lemmetyinen, H., Langer, R., Anderson, D.G., Urtti, A., Yliperttula, M. Poly(beta-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies. Journal of Controlled Release. 2011; 154(2):171-6. doi: 10.1016/j.jconrel.2011.06.016. PMCID: PMC3362269.

Cheng, H., Hill, P.S., Siegwart, D.J., Vacanti, N., Lytton-Jean, A.K., Cho, S.W., Ye, A., Langer, R., Anderson, D.G. A novel family of biodegradable poly(ester amide) elastomers. Advanced Materials. 2011; 23(12):H95-100. doi: 10.1002/adma.201003482. PMCID: PMC3893923.

Timko, B.P., Whitehead, K., Gao, W., Kohane, D.S., Farokhzad, O., Anderson, D.G., Langer, R. Advances in Drug Delivery. Annual Review of Materials Research. 2011; 41(1):1-20. doi: doi:10.1146/annurev-matsci-062910-100359.

O'Sullivan, E.S., Vegas, A., Anderson, D.G., Weir, G.C. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocrine Reviews. 2011; 32(6):827-44. doi: 10.1210/er.2010-0026. PMCID: PMC3591674.


Yang, F., Cho, S.W., Son, S.M., Bogatyrev, S.R., Singh, D., Green, J.J., Mei, Y., Park, S., Bhang, S.H., Kim, B.S., Langer, R., Anderson, D.G. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A. 2010; 107(8):3317-22. doi: 10.1073/pnas.0905432106. PMCID: PMC2840438.

Harris, T.J., Green, J.J., Fung, P.W., Langer, R., Anderson, D.G., Bhatia, S.N. Tissue-specific gene delivery via nanoparticle coating. Biomaterials. 2010; 31(5):998-1006. doi: 10.1016/j.biomaterials.2009.10.012. PMCID: PMC2796451.

Schroeder, A., Levins, C.G., Cortez, C., Langer, R., Anderson, D.G. Lipid-based nanotherapeutics for siRNA delivery. Journal of Internal Medicine. 2010; 267(1):9-21. doi: 10.1111/j.1365-2796.2009.02189.x. PMCID: PMC5308083.

Love, K.T., Mahon, K.P., Levins, C.G., Whitehead, K.A., Querbes, W., Dorkin, J.R., Qin, J., Cantley, W., Qin, L.L., Racie, T., Frank-Kamenetsky, M., Yip, K.N., Alvarez, R., Sah, D.W., de Fougerolles, A., Fitzgerald, K., Koteliansky, V., Akinc, A., Langer, R., Anderson, D.G. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A. 2010; 107(5):1864-9. doi: 10.1073/pnas.0910603106. PMCID: PMC2804742.

Hook, A.L., Anderson, D.G., Langer, R., Williams, P., Davies, M.C., Alexander, M.R. High throughput methods applied in biomaterial development and discovery. Biomaterials. 2010; 31(2):187-98. doi: 10.1016/j.biomaterials.2009.09.037. PMID: 19815273.

Cheng, H., Kastrup, C.J., Ramanathan, R., Siegwart, D.J., Ma, M., Bogatyrev, S.R., Xu, Q., Whitehead, K.A., Langer, R., Anderson, D.G. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano. 2010; 4(2):625-31. doi: 10.1021/nn901319y. PMCID: PMC2836800.

Bratlie, K.M., Dang, T.T., Lyle, S., Nahrendorf, M., Weissleder, R., Langer, R., Anderson, D.G. Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS One. 2010; 5(4):e10032. doi: 10.1371/journal.pone.0010032. PMCID: PMC2850367.

Shmueli, R.B., Anderson, D.G., Green, J.J. Electrostatic surface modifications to improve gene delivery. Expert Opinion on Drug Delivery. 2010; 7(4):535-50. doi: 10.1517/17425241003603653. PMCID: PMC2911010.

Davies, M.C., Alexander, M.R., Hook, A.L., Yang, J., Mei, Y., Taylor, M., Urquhart, A.J., Langer, R., Anderson, D.G. High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays. Journal of Drug Targeting. 2010; 18(10):741-51. doi: 10.3109/1061186X.2010.521941. PMID: 20945971.

Yang, F., Cho, S.W., Son, S.M., Hudson, S.P., Bogatyrev, S., Keung, L., Kohane, D.S., Langer, R., Anderson, D.G. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010; 11(8):1909-14. doi: 10.1021/bm100357t. PMCID: PMC2946176.

Mei, Y., Hollister-Lock, J., Bogatyrev, S.R., Cho, S.W., Weir, G.C., Langer, R., Anderson, D.G. A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials. 2010; 31(34):8989-95. doi: 10.1016/j.biomaterials.2010.08.029. PMCID: PMC3415986.

Cigler, P., Lytton-Jean, A.K., Anderson, D.G., Finn, M.G., Park, S.Y. DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and protein nanoparticles. Nature Materials. 2010; 9(11):918-22. doi: 10.1038/nmat2877. PMCID: PMC4006348.

Huang, Y.H., Cozzitorto, J.A., Richards, N.G., Eltoukhy, A.A., Yeo, C.J., Langer, R., Anderson, D.G., Brody, J.R., Sawicki, J.A. CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy. Cancer Biology & Therapy. 2010; 10(9):878-84. doi: 10.4161/cbt.10.9.13234. PMCID: PMC3040857.

Mahon, K.P., Love, K.T., Whitehead, K.A., Qin, J., Akinc, A., Leshchiner, E., Leshchiner, I., Langer, R., Anderson, D.G. Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery. Bioconjugate Chemistry. 2010; 21(8):1448-54. doi: 10.1021/bc100041r. PMCID: PMC2931596.

Yang, J., Mei, Y., Hook, A.L., Taylor, M., Urquhart, A.J., Bogatyrev, S.R., Langer, R., Anderson, D.G., Davies, M.C., Alexander, M.R. Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays. Biomaterials. 2010; 31(34):8827-38. doi: 10.1016/j.biomaterials.2010.08.028. PMCID: PMC2992358.

De Sousa, F.B., Guerreiro, J.D.T., Ma, M., Anderson, D.G., Drum, C.L., Sinisterra, R.D., Langer, R. Photo-response behavior of electrospun nanofibers based on spiropyran-cyclodextrin modified polymer. Journal of Materials Chemistry. 2010; 20(44):9910-7. doi: 10.1039/C0JM01903H. PMCID: PMC5307972.

Mei, Y., Saha, K., Bogatyrev, S.R., Yang, J., Hook, A.L., Kalcioglu, Z.I., Cho, S.W., Mitalipova, M., Pyzocha, N., Rojas, F., Van Vliet, K.J., Davies, M.C., Alexander, M.R., Langer, R., Jaenisch, R., Anderson, D.G. Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nature Materials. 2010; 9(9):768-78. doi: 10.1038/nmat2812. PMCID: PMC3388774.


Huang, Y.H., Bao, Y., Peng, W., Goldberg, M., Love, K., Bumcrot, D.A., Cole, G., Langer, R., Anderson, D.G., Sawicki, J.A. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci U S A. 2009; 106(9):3426-30. doi: 10.1073/pnas.0813348106. PMCID: PMC2651300.

Yang, F., Green, J.J., Dinio, T., Keung, L., Cho, S.W., Park, H., Langer, R., Anderson, D.G. Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors. Gene Therapy. 2009; 16(4):533-46. doi: 10.1038/gt.2008.182. PMCID: PMC2688702.

Nguyen, D.N., Green, J.J., Chan, J.M., Langer, R., Anderson, D.G. Polymeric Materials for Gene Delivery and DNA Vaccination. Advanced Materials. 2009; 21(8):847-67. doi: 10.1002/adma.200801478.

Whitehead, K.A., Langer, R., Anderson, D.G. Knocking down barriers: advances in siRNA delivery. Nature Reviews Drug Discovery. 2009; 8(2):129-38. PMID: 19180106.

Mei, Y., Gerecht, S., Taylor, M., Urquhart, A.J., Bogatyrev, S.R., Cho, S-W., Davies, M.C., Alexander, M.R., Langer, R.S., Anderson, D.G. Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells. Advanced Materials. 2009; 21(27):2781-6. doi: 10.1002/adma.200803184.

Yang, F., Mei, Y., Langer, R., Anderson, D.G. High throughput optimization of stem cell microenvironments. Combinatorial Chemistry & High Throughput Screening. 2009; 12(6):554-61. PMCID: PMC2748120.

Xu, Q., Hashimoto, M., Dang, T.T., Hoare, T., Kohane, D.S., Whitesides, G.M., Langer, R., Anderson, D.G. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009; 5(13):1575-81. doi: 10.1002/smll.200801855. PMCID: PMC2789598.

Akinc, A., Goldberg, M., Qin, J., Dorkin, J.R., Gamba-Vitalo, C., Maier, M., Jayaprakash, K.N., Jayaraman, M., Rajeev, K.G., Manoharan, M., Koteliansky, V., Röhl, I., Leshchiner, E.S., Langer, R., Anderson, D.G. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Molecular Therapy. 2009; 17(5):872-9. doi: 10.1038/mt.2009.36. PMCID: PMC2835134.

Taylor, M., Urquhart, A.J., Anderson, D.G., Langer, R., Davies, M.C., Alexander, M.R. Partial least squares regression as a powerful tool for investigating large combinatorial polymer libraries. Surface and Interface Analysis. 2009; 41(2):127-35. doi: 10.1002/sia.2969. PMCID: PMC4235767.

Zhou, M., Liu, H., Kilduff, J.E., Langer, R., Anderson, D.G., Belfort, G. High-throughput membrane surface modification to control NOM fouling. Environmental and Science Technology. 2009; 43(10):3865-71. PMID: 19544900.

Bhang, S.H., Cho, S.W., Lim, J.M., Kang, J.M., Lee, T.J., Yang, H.S., Song, Y.S., Park, M.H., Kim, H.S., Yoo, K.J., Jang, Y., Langer, R., Anderson, D.G., Kim, B.S. Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells. 2009; 27(8):1976-86. doi: 10.1002/stem.115. PMCID: PMC5215850.

Nguyen, D.N., Kim, P., Martinez-Sobrido, L., Beitzel, B., Garcia-Sastre, A., Langer, R., Anderson, D.G. A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery. Biotechnology and Bioengineering. 2009; 103(4):664-75. doi: 10.1002/bit.22312. PMCID: PMC2771114.

Huang, Y.H., Zugates, G.T., Peng, W., Holtz, D., Dunton, C., Green, J.J., Hossain, N., Chernick, M.R., Padera, R.F., Jr., Langer, R., Anderson, D.G., Sawicki, J.A. Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice. Cancer Research. 2009; 69(15):6184-91. doi: 10.1158/0008-5472.CAN-09-0061. PMCID: PMC2735403.

Cho, S.W., Goldberg, M., Son, S.M., Xu, Q., Yang, F., Mei, Y., Bogatyrev, S., Langer, R., Anderson, D.G. Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells. Advanced Functional Materials. 2009; 19(19):3112-8. doi: 10.1002/adfm.200900519. PMCID: PMC3564673.

Sunshine, J., Green, J.J., Mahon, K.P., Yang, F., Eltoukhy, A.A., Nguyen, D.N., Langer, R., Anderson, D.G. Small Molecule End Groups of Linear Polymer Determine Cell-type Gene Delivery Efficacy. Advanced Materials. 2009; 21(48):4947-51. doi: 10.1002/adma.200901718. PMCID: PMC4143259.

Nguyen, D.N., Chen, S.C., Lu, J., Goldberg, M., Kim, P., Sprague, A., Novobrantseva, T., Sherman, J., Shulga-Morskaya, S., de Fougerolles, A., Chen, J., Langer, R., Anderson, D.G. Drug delivery-mediated control of RNA immunostimulation. Molecular Therapy. 2009; 17(9):1555-62. doi: 10.1038/mt.2009.147. PMCID: PMC2835254.

Lee, J.S., Green, J.J., Love, K.T., Sunshine, J., Langer, R., Anderson, D.G. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Letters. 2009; 9(6):2402-6. doi: 10.1021/nl9009793. PMCID: PMC2728206.

Karagiannis, E.D., Anderson, D.G. Minicells overcome tumor drug-resistance. Nature Biotechnology. 2009; 27(7):620-1. doi: 10.1038/nbt0709-620. PMID: 19587665.

Dang, T.T., Xu, Q., Bratlie, K.M., O'Sullivan, E.S., Chen, X.Y., Langer, R., Anderson, D.G. Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules. Biomaterials. 2009; 30(36):6896-902. doi: 10.1016/j.biomaterials.2009.09.012. PMCID: PMC5245869.

Stone, G.W., Barzee, S., Snarsky, V., Santucci, C., Tran, B., Langer, R., Zugates, G.T., Anderson, D.G., Kornbluth, R.S. Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma. PLoS One. 2009; 4(10):e7334. doi: 10.1371/journal.pone.0007334. PMCID: PMC2754331.


Urquhart, A.J., Taylor, M., Anderson, D.G., Langer, R., Davies, M.C., Alexander, M.R. TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettability. Analytical Chemistry. 2008; 80(1):135-42. doi: 10.1021/ac071560k. PMID: 18044847.

Green, J.J., Langer, R., Anderson, D.G. A combinatorial polymer library approach yields insight into nonviral gene delivery. Accounts of Chemical Research. 2008;41(6):749-59. doi: 10.1021/ar7002336. PMCID: PMC3490629.

Karnik, R., Hong, S., Zhang, H., Mei, Y., Anderson, D.G., Karp, J.M., Langer, R. Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors. Nano Letters. 2008; 8(4):1153-8. doi: 10.1021/nl073322a. PMCID: PMC2911031.

Goldberg, M., Mahon, K., Anderson, D. Combinatorial and rational approaches to polymer synthesis for medicine. Advanced Drug Delivery Reviews. 2008; 60(9):971-8. doi: 10.1016/j.addr.2008.02.005. PMCID: PMC2536566.

Akinc, A., Zumbuehl, A., Goldberg, M., Leshchiner, E.S., Busini, V., Hossain, N., Bacallado, S.A., Nguyen, D.N., Fuller, J., Alvarez, R., Borodovsky, A., Borland, T., Constien, R., de Fougerolles, A., Dorkin, J.R., Narayanannair Jayaprakash, K., Jayaraman, M., John, M., Koteliansky, V., Manoharan, M., Nechev, L., Qin, J., Racie, T., Raitcheva, D., Rajeev, K.G., Sah, D.W., Soutschek, J., Toudjarska, I., Vornlocher, H.P., Zimmermann, T.S., Langer, R., Anderson, D.G. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nature Biotechnoly. 2008; 26(5):561-9. doi: 10.1038/nbt1402. PMCID: PMC3014085.

Epiphanio, S., Mikolajczak, S.A., Goncalves, L.A., Pamplona, A., Portugal, S., Albuquerque, S., Goldberg, M., Rebelo, S., Anderson, D.G., Akinc, A., Vornlocher, H.P., Kappe, S.H., Soares, M.P., Mota, M.M. Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Cell Host Microbe. 2008; 3(5):331-8. doi: 10.1016/j.chom.2008.04.003. PMID: 18474360.

Taylor, M., Urquhart, A.J., Anderson, D.G., Williams, P.M., Langer, R., Alexander, M.R., Davies, M.C. A Methodology for Investigating Protein Adhesion and Adsorption to Microarrayed Combinatorial Polymers. Macromolecular Rapid Communications. 2008; 29(15):1298-302. doi: 10.1002/marc.200800171.

Frank-Kamenetsky, M., Grefhorst, A., Anderson, N.N., Racie, T.S., Bramlage, B., Akinc, A., Butler, D., Charisse, K., Dorkin, R., Fan, Y., Gamba-Vitalo, C., Hadwiger, P., Jayaraman, M., John, M., Jayaprakash, K.N., Maier, M., Nechev, L., Rajeev, K.G., Read, T., Rohl, I., Soutschek, J., Tan, P., Wong, J., Wang, G., Zimmermann, T., de Fougerolles, A., Vornlocher, H.P., Langer, R., Anderson, D.G., Manoharan, M., Koteliansky, V., Horton, J.D., Fitzgerald, K. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A. 2008; 105(33):11915-20. doi: 10.1073/pnas.0805434105. PMCID: PMC2575310.

Green, J.J., Zhou, B.Y., Mitalipova, M.M., Beard, C., Langer, R., Jaenisch, R., Anderson, D.G. Nanoparticles for gene transfer to human embryonic stem cell colonies. Nano Letters. 2008; 8(10):3126-30. doi: 10.1021/nl8012665. PMCID: PMC3814161.

Mei, Y., Cannizzaro, C., Park, H., Xu, Q., Bogatyrev, S.R., Yi, K., Goldman, N., Langer, R., Anderson, D.G. Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Small. 2008; 4(10):1600-4. doi: 10.1002/smll.200800363. PMCID: PMC2679812.

Showalter, S.L., Huang, Y.H., Witkiewicz, A., Costantino, C.L., Yeo, C.J., Green, J.J., Langer, R., Anderson, D.G., Sawicki, J.A., Brody, J.R. Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells. Cancer Biology & Therapy. 2008; 7(10):1584-90. PMCID: PMC3218426.

Svensson, R.U., Shey, M.R., Ballas, Z.K., Dorkin, J.R., Goldberg, M, Akinc, A., Langer, R., Anderson, D.G., Bumcrot, D., Henry, M.D. Assessing siRNA pharmacodynamics in a luciferase-expressing mouse. Molecular Therapy. 2008; 16(12):1995-2001. doi: 10.1038/mt.2008.187. PMCID: PMC3014086.

Cho, S.W., Hartle, L., Son, S.M., Yang, F., Goldberg, M., Xu, Q., Langer, R., Anderson, D.G. Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. Biochemical and Biophysical Research Communications. 2008; 376(1):158-63. doi: 10.1016/j.bbrc.2008.08.123. PMCID: PMC3957099.


Peng, W., Anderson, D.G., Bao, Y., Padera Jr., R.F., Langer, R., Sawicki, J.A. Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors. Prostate. 2007; 67(8):855-62.. doi: 10.1002/pros.20576. PMID: 17427200.

Green, J.J., Chiu, E., Leshchiner, E.S., Shi, J., Langer, R., Anderson, D.G. Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells. Nano Letters. 2007; 7(4):874-9. doi: 10.1021/nl062395b. PMID: 17362046.

Zugates, G.T., Peng, W., Zumbuehl, A., Jhunjhunwala, S., Huang, Y.H., Langer, R., Sawicki, J.A., Anderson, D.G. Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s. Molecular Therapy. 2007; 15(7):1306-12. doi: 10.1038/ PMID: 17375071.

Mei, Y., Goldberg, M., Anderson, D.G. The development of high-throughput screening approaches for stem cell engineering. Current Opinion in Chemical Biology. 2007; 11(4):388-93. doi: 10.1016/j.cbpa.2007.07.006. PMCID: PMC3017753.

Green, J.J., Zugates, G.T., Tedford, N.C., Huang, Y.H., Griffith, L.G., Lauffenburger, D.A., Sawicki, J.A., Langer, R., Anderson, D.G. Combinatorial Modification of Degradable Polymers Enables Transfection of Human Cells Comparable to Adenovirus. Advanced Materials. 2007; 19(19):2836-42. doi: 10.1002/adma.200700371.

Urquhart, A.J., Anderson, D.G., Taylor, M., Alexander, M.R., Langer, R., Davies, M.C. High Throughput Surface Characterisation of a Combinatorial Material Library. Advanced Materials. 2007; 19(18):2486-91. doi: 10.1002/adma.200700949.

John, M., Constien, R., Akinc,A., Goldberg, M., Moon, Y.A., Spranger, M., Hadwiger, P., Soutschek, J., Vornlocher, H.P., Manoharan, M., Stoffel, M., Langer, R., Anderson, D.G., Horton, J.D., Koteliansky, V., Bumcrot, D. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature. 2007; 449(7163):745-7. doi: 10.1038/nature06179. PMCID: PMC3019095.

Zugates, G.T., Tedford, N.C., Zumbuehl, A., Jhunjhunwala, S., Kang, C.S., Griffith, L.G., Lauffenburger, D.A., Langer, R., Anderson, D.G. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate Chemistry. 2007; 18(6):1887-96. doi: 10.1021/bc7002082. PMID: 17929884.


Anderson, D.G., Tweedie, C.A., Hossain, N., Navarro, S.M., Brey, D.M., Van Vliet, K.J., Langer, R., Burdick, J.A. A Combinatorial Library of Photocrosslinkable and Degradable Materials. Advanced Materials. 2006; 18(19):2614-8. doi: 10.1002/adma.200600529.

Zugates, G.T., Anderson, D.G., Little, S.R., Lawhorn, I.E., Langer, R. Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery. Journal of the American Chemical Society. 2006; 128(39):12726-34. Epub 2006/09/28. doi: 10.1021/ja061570n. PMID: 17002366.

Green, J.J., Shi, J., Chiu, E., Leshchiner, E.S., Langer, R., Anderson, D.G. Biodegradable polymeric vectors for gene delivery to human endothelial cells. Bioconjugate Chemistry. 2006; 17(5):1162-9. doi: 10.1021/bc0600968. PMID: 16984124.


Anderson, D.G., Putnam, D., Lavik, E.B., Mahmood, T.A., Langer, R. Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction. Biomaterials. 2005; 26(23):4892-7. doi: 10.1016/j.biomaterials.2004.11.052. PMID: 15763269.

Anderson, D.G., Akinc, A,. Hossain, N., Langer, R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Molecular Therapy. 2005; 11(3):426-34. doi: 10.1016/j.ymthe.2004.11.015. PMID: 15727939.

Greenland, J.R., Liu, H., Berry, D., Anderson, D.G., Kim, W.K., Irvine, D.J., Langer, R., Letvin,N.L. Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Molecular Therapy. 2005; 12(1):164-70. doi: 10.1016/j.ymthe.2005.01.021. PMID: 15963932.

Stevens, M.M., Mayer, M., Anderson, D.G., Weibel, D.B., Whitesides, G.M., Langer, R. Direct patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps. Biomaterials. 2005; 26(36):7636-41. doi: 10.1016/j.biomaterials.2005.05.001. PMID: 15979701.

Zugates, G.T., Little, S.R., Anderson, D.G., Langer, R. Poly(ß-amino ester)s for DNA delivery. Israel Journal of Chemistry. 2005; 45(4):477-85. doi: 10.1560/7C67-5X19-PEJ8-PXUN.

Tweedie, C.A., Anderson, D.G., Langer, R., Van Vliet, K.J. Combinatorial Material Mechanics: High-Throughput Polymer Synthesis and Nanomechanical Screening. Advanced Materials. 2005; 17(21):2599-604. doi: 10.1002/adma.200501142.


Little, S.R., Lynn, D.M., Ge, Q., Anderson, D.G., Puram, S.V., Chen, J., Eisen, H.N., Langer, R. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004; 101(26):9534-9. doi: 10.1073/pnas.0403549101. PMCID: PMC470709.

Haining, W.N., Anderson, D.G., Little, S.R., von Bergwelt-Baildon, M.S., Cardoso, A.A., Alves, P., Kosmatopoulos, K., Nadler, L.M., Langer, R., Kohane, D.S. pH-triggered microparticles for peptide vaccination. J Immunol. 2004; 173(4):2578-85. PMID: 15294974.

Anderson, D.G., Burdick, J.A., Langer, R. Materials science. Smart biomaterials. Science. 2004; 305(5692):1923-4. doi: 10.1126/science.1099987. PMID: 15448260.

Anderson, D.G., Levenberg, S., Langer, R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol. 2004; 22(7):863-6. doi: 10.1038/nbt981. PMID: 15195101.

Anderson, D.G., Peng, W., Akinc, A., Hossain, N., Kohn, A., Padera, R., Langer, R., Sawicki, J.A. A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sci U S A. 2004; 101(45):16028-33. doi: 10.1073/pnas.0407218101. PMCID: PMC528737.


Akinc, A., Lynn, D.M., Anderson, D.G., Langer, R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. Journal of the American Chemical Society. 2003; 125(18):5316-23. doi: 10.1021/ja034429c. PMID: 12720443.

Anderson, D.G., Lynn, D.M., Langer, R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl. 2003; 42(27):3153-8. doi: 10.1002/anie.200351244. PMID: 12866105.

Akinc, A., Anderson, D.G., Lynn, D.M., Langer, R. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjugate Chemistry. 2003; 14(5):979-88. doi: 10.1021/bc034067y. PMID: 13129402.

Jon, S., Anderson, D.G., Langer, R. Degradable poly(amino alcohol esters) as potential DNA vectors with low cytotoxicity. Biomacromolecules. 2003; 4(6):1759-62. doi: 10.1021/bm034176f. PMID: 14606906.

Kohane, D.S., Anderson, D.G., Yu, C., Langer, R. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharmaceutical Research. 2003; 20(10):1533-8. PMID: 14620503.


Lynn, D.M., Anderson, D.G., Putnam, D., Langer, R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. Journal of the American Chemical Society. 2001; 123(33):8155-6. PMID: 11506588.


Anderson, D.G., Churchill, J.J., Kowalczykowski, S.C. A single mutation, RecB(D1080A,) eliminates RecA protein loading but not Chi recognition by RecBCD enzyme. Journal of Biological Chemistry. 1999; 274(38):27139-44. PMID: 10480929.

Churchill, J.J., Anderson, D.G., Kowalczykowski, S.C. The RecBC enzyme loads RecA protein onto ssDNA asymmetrically and independently of chi, resulting in constitutive recombination activation. Genes and Development. 1999; 13(7):901-11. PMCID: PMC316600.


Anderson, D.G., Kowalczykowski, S.C. Reconstitution of an SOS response pathway: derepression of transcription in response to DNA breaks. Cell. 1998; 95(7):975-9. PMID: 9875851.

Anderson, D.G., Kowalczykowski, S.C. SSB protein controls RecBCD enzyme nuclease activity during unwinding: a new role for looped intermediates. Journal of Molecular Biology. 1998; 282(2):275-85. doi: 10.1006/jmbi.1998.2013. PMID: 9735287.


Anderson, D.G., Kowalczykowski, S.C. The translocating RecBCD enzyme stimulates recombination by directing RecA protein onto ssDNA in a chi-regulated manner. Cell. 1997; 90(1):77-86. PMID: 9230304.

Anderson, D.G., Kowalczykowski, S.C. The recombination hot spot chi is a regulatory element that switches the polarity of DNA degradation by the RecBCD enzyme. Genes and Development. 1997; 11(5):571-81. PMID: 9119222.

Anderson, D.G., Churchill, J.J., Kowalczykowski, S.C. Chi-activated RecBCD enzyme possesses 5'-->3' nucleolytic activity, but RecBC enzyme does not: evidence suggesting that the alteration induced by Chi is not simply ejection of the RecD subunit. Genes to Cells. 1997; 2(2):117-28. PMID: 9167969.