Publications

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Recent Publications (2014)

Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proc Natl Acad Sci U S A. 2014. doi: 10.1073/pnas.1322937111. PMID: 24516150.

Hook AL, Chang CY, Scurr DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment. Adv Healthc Mater. 2014. doi: 10.1002/adhm.201300518. PMID: 24497458.

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2013

Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2013. doi: 10.1016/j.jacc.2013.11.023. PMID: 24361318.

Kanasty R, Dorkin JR, Vegas A, Anderson D. Delivery materials for siRNA therapeutics. Nat Mater. 2013;12(11):967-77. doi: 10.1038/nmat3765. PMID: 24150415.

Gu Z, Dang TT, Ma M, Tang BC, Cheng H, Jiang S, Dong Y, Zhang Y, Anderson DG. Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery. ACS Nano. 2013;7(8):6758-66. doi: 10.1021/nn401617u. PMID: 23834678.

Guo L, Ma M, Zhang N, Langer R, Anderson DG. Stretchable Polymeric Multielectrode Array for Conformal Neural Interfacing. Advanced Materials. 2013. doi: 10.1002/adma.201304140. PMID: 24150828.

Li W, Lee S, Ma M, Kim SM, Guye P, Pancoast JR, Anderson DG, Weiss R, Lee RT, Hammond PT. Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic beta-cells. Sci Rep. 2013;3:2863. doi: 10.1038/srep02863. PMCID: PMC3790197.

Invernale MA, Tang BC, York RL, Le L, Hou DY, Anderson DG. Microneedle Electrodes Toward an Amperometric Glucose-Sensing Smart Patch. Adv Healthc Mater. 2013. doi: 10.1002/adhm.201300142. PMID: 24039157.

Karagiannis ED, Urbanska AM, Sahay G, Pelet JM, Jhunjhunwala S, Langer R, Anderson DG. Rational design of a biomimetic cell penetrating peptide library. ACS Nano. 2013;7(10):8616-26. doi: 10.1021/nn4027382. PMID: 24047542.

Zugates GT, Anderson DG, Langer R. High-throughput methods for screening polymeric transfection reagents. Cold Spring Harb Protoc. 2013;2013(11). doi: 10.1101/pdb.prot078634. PMID: 24184768.

Zhang Y, Pelet JM, Heller DA, Dong Y, Chen D, Gu Z, Joseph BJ, Wallas J, Anderson DG. Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery. Advanced Materials. 2013;25(33):4641-5. doi: 10.1002/adma.201301917. PMID: 23813808.

Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation. 2013;127(20):2038-46. doi: 10.1161/CIRCULATIONAHA.112.000116.  PMCID: PMC3661714.

Dang TT, Thai AV, Cohen J, Slosberg JE, Siniakowicz K, Doloff JC, Ma M, Hollister-Lock J, Tang KM, Gu Z, Cheng H, Weir GC, Langer R, Anderson DG. Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug. Biomaterials. 2013;34(23):5792-801. doi: 10.1016/j.biomaterials.2013.04.016. PMID: 23660251.

Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol. 2013;31(7):653-8. doi: 10.1038/nbt.2614. PMCID: PMC3814166.

Gu M, Vegas AJ, Anderson DG, Langer RS, Kilduff JE, Belfort G. Combinatorial synthesis with high throughput discovery of protein-resistant membrane surfaces. Biomaterials. 2013;34(26):6133-8. doi: 10.1016/j.biomaterials.2013.04.051. PMID: 23706542.

Alabi CA, Love KT, Sahay G, Yin H, Luly KM, Langer R, Anderson DG. Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery. Proc Natl Acad Sci U S A. 2013;110(32):12881-6. doi: 10.1073/pnas.1306529110. PMCID: PMC3740846.

Mizrahi B, Shankarappa SA, Hickey JM, Dohlman JC, Timko BP, Whitehead KA, Lee JJ, Langer R, Anderson DG, Kohane DS. A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013;23(12):1527-33. doi: 10.1002/adfm.201202433.  PMCID: PMC3646576.

Gu Z, Aimetti AA, Wang Q, Dang TT, Zhang Y, Veiseh O, Cheng H, Langer RS, Anderson DG. Injectable nano-network for glucose-mediated insulin delivery. ACS Nano. 2013;7(5):4194-201. doi: 10.1021/nn400630x. PMID: 23638642.

Hook AL, Chang CY, Yang J, Atkinson S, Langer R, Anderson DG, Davies MC, Williams P, Alexander MR. Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials. 2013;25(18):2542-7. doi: 10.1002/adma.201204936. PMCID: PMC3736217.

Majmudar MD, Yoo J, Keliher EJ, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques. Circ Res. 2013;112(5):755-61. doi: 10.1161/CIRCRESAHA.111.300576.  PMCID: PMC3586287.

Jiang S, Eltoukhy AA, Love KT, Langer R, Anderson DG. Lipidoid-coated iron oxide nanoparticles for efficient DNA and siRNA delivery. Nano Lett. 2013;13(3):1059-64. doi: 10.1021/nl304287a. PMID: 23394319.

Haq R, Yokoyama S, Hawryluk EB, Jonsson GB, Frederick DT, McHenry K, Porter D, Tran TN, Love KT, Langer R, Anderson DG, Garraway LA, Duncan LM, Morton DL, Hoon DS, Wargo JA, Song JS, Fisher DE. BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition. Proc Natl Acad Sci U S A. 2013;110(11):4321-6. doi: 10.1073/pnas.1205575110. PMCID: PMC3600451.

Hook AL, Scurr DJ, Burley JC, Langer R, Anderson DG, Davies MC, Alexander MR. Analysis and prediction of defects in UV photo-initiated polymer microarrays. Journal of Materials Chemistry B. 2013;1(7):1035-43. doi: 10.1039/C2TB00379A.

Scurr DJ, Hook AL, Burley JA, Williams PM, Anderson DG, Langer RC, Davies MC, Alexander MR. Strategies for MCR image analysis of large hyperspectral data-sets. Surface and Interface Analysis. 2013;45(1):466-70. doi: 10.1002/sia.5040. PMCID: PMC3579489.

Celiz AD, Hook AL, Scurr DJ, Anderson DG, Langer R, Davies MC, Alexander MR. ToF-SIMS imaging of a polymer microarray prepared using ink-jet printing of acrylate monomers. Surface and Interface Analysis. 2013;45(1):202-5. doi: 10.1002/sia.5042.

Hook AL, Scurr DJ, Anderson DG, Langer R, Williams P, Davies M, Alexander M. High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry. Surface and Interface Analysis. 2013;45(1):181-4. doi: 10.1002/sia.4910. PMCID: PMC3579490.

Sharei A, Zoldan J, Adamo A, Sim WY, Cho N, Jackson E, Mao S, Schneider S, Han MJ, Lytton-Jean A, Basto PA, Jhunjhunwala S, Lee J, Heller DA, Kang JW, Hartoularos GC, Kim KS, Anderson DG, Langer R, Jensen KF. A vector-free microfluidic platform for intracellular delivery. Proc Natl Acad Sci U S A. 2013;110(6):2082-7. doi: 10.1073/pnas.1218705110. PMCID: PMC3568376.

Ma M, Guo L, Anderson DG, Langer R. Bio-inspired polymer composite actuator and generator driven by water gradients. Science. 2013;339(6116):186-9. doi: 10.1126/science.1230262. PMCID: PMC3635810.

Eltoukhy AA, Chen D, Alabi CA, Langer R, Anderson DG. Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability. Advanced Materials. 2013;25(10):1487-93. doi: 10.1002/adma.201204346. PMCID: PMC3824380.

Ma M, Chiu A, Sahay G, Doloff JC, Dholakia N, Thakrar R, Cohen J, Vegas A, Chen D, Bratlie KM, Dang T, York RL, Hollister-Lock J, Weir GC, Anderson DG. Core-shell hydrogel microcapsules for improved islets encapsulation. Adv Healthc Mater. 2013;2(5):667-72. doi: 10.1002/adhm.201200341. PMCID: PMC3814167.

Heller DA, Levi Y, Pelet JM, Doloff JC, Wallas J, Pratt GW, Jiang S, Sahay G, Schroeder A, Schroeder JE, Chyan Y, Zurenko C, Querbes W, Manzano M, Kohane DS, Langer R, Anderson DG. Modular 'click-in-emulsion' bone-targeted nanogels. Advanced Materials. 2013;25(10):1449-54. doi: 10.1002/adma.201202881. PMCID: PMC3815631.

Alabi CA, Sahay G, Langer R, Anderson DG. Development of siRNA-probes for studying intracellular trafficking of siRNA nanoparticles. Integrative Biology. 2013;5(1):224-30. doi: 10.1039/c2ib20155k. PMCID: PMC3524365.

Peng W, Dunton C, Holtz D, Parva M, Stampler K, Forwood M, Gogoi R, Lace MJ, Anderson DG, Sawicki JA. DNA nanotherapy for pre-neoplastic cervical lesions. Gynecol Oncol. 2013;128(1):101-6. doi: 10.1016/j.ygyno.2012.10.018. PMID: 23103931.

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2012

Kastrup CJ, Nahrendorf M, Figueiredo JL, Lee H, Kambhampati S, Lee T, Cho SW, Gorbatov R, Iwamoto Y, Dang TT, Dutta P, Yeon JH, Cheng H, Pritchard CD, Vegas AJ, Siegel CD, MacDougall S, Okonkwo M, Thai A, Stone JR, Coury AJ, Weissleder R, Langer R, Anderson DG. Painting blood vessels and atherosclerotic plaques with an adhesive drug depot. Proc Natl Acad Sci U S A. 2012;109(52):21444-9. doi: 10.1073/pnas.1217972110. PMCID: PMC3535589.

Epa VC, Yang J, Mei Y, Hook AL, Langer R, Anderson DG, Davies MC, Alexander MR, Winkler DA. Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry. 2012;22(39):20902-6. doi: 10.1039/C2JM34782B. PMCID: PMC3787298.

Hook AL, Chang CY, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R, Irvine DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. Combinatorial discovery of polymers resistant to bacterial attachment. Nat Biotechnol. 2012;30(9):868-75. doi: 10.1038/nbt.2316.  PMCID: PMC3796337.

Bratlie KM, York RL, Invernale MA, Langer R, Anderson DG. Materials for diabetes therapeutics. Adv Healthc Mater. 2012;1(3):267-84. doi: 10.1002/adhm.201200037. PMCID: PMC3899887.

Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF regulates TGF-beta signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012;2(6):1684-96. doi: 10.1016/j.celrep.2012.10.021. PMCID: PMC3534912.

Karagiannis ED, Alabi CA, Anderson DG. Rationally designed tumor-penetrating nanocomplexes. ACS Nano. 2012;6(10):8484-7. doi: 10.1021/nn304707b. PMID: 23088785.

Li J, Song JS, Bell RJ, Tran TN, Haq R, Liu H, Love KT, Langer R, Anderson DG, Larue L, Fisher DE. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688. doi: 10.1371/journal.pgen.1002688.  PMCID: PMC3342948.

Schroeder A, Goldberg MS, Kastrup C, Wang Y, Jiang S, Joseph BJ, Levins CG, Kannan ST, Langer R, Anderson DG. Remotely activated protein-producing nanoparticles. Nano Lett. 2012;12(6):2685-9. doi: 10.1021/nl2036047. PMCID: PMC3388722.

Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG. Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics. Biomaterials. 2012;33(20):5004-12. doi: 10.1016/j.biomaterials.2012.03.065. PMCID: PMC3366278.

Alabi CA, Love KT, Sahay G, Stutzman T, Young WT, Langer R, Anderson DG. FRET-labeled siRNA probes for tracking assembly and disassembly of siRNA nanocomplexes. ACS Nano. 2012;6(7):6133-41. doi: 10.1021/nn3013838. PMCID: PMC3404193.

Whitehead KA, Matthews J, Chang PH, Niroui F, Dorkin JR, Severgnini M, Anderson DG. In vitro-in vivo translation of lipid nanoparticles for hepatocellular siRNA delivery. ACS Nano. 2012;6(8):6922-9. doi: 10.1021/nn301922x. PMCID: PMC3429655.

Weldon CB, Tsui JH, Shankarappa SA, Nguyen VT, Ma M, Anderson DG, Kohane DS. Electrospun drug-eluting sutures for local anesthesia. Journal of Controlled Release. 2012;161(3):903-9. doi: 10.1016/j.jconrel.2012.05.021. PMCID: PMC3412890.

Vacanti NM, Cheng H, Hill PS, Guerreiro JD, Dang TT, Ma M, Watson S, Hwang NS, Langer R, Anderson DG. Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response. Biomacromolecules. 2012;13(10):3031-8. doi: 10.1021/bm300520u. PMCID: PMC3466020.

Kang SM, Hwang NS, Yeom J, Park SY, Messersmith PB, Choi IS, Langer R, Anderson DG, Lee H. One-Step Multipurpose Surface Functionalization by Adhesive Catecholamine. Adv Funct Mater. 2012;22(14):2949-55. doi: 10.1002/adfm.201200177. PMCID: PMC3619432.

Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, Jeon A, Dong Y, Whitehead KA, Anderson DG. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. Journal of the American Chemical Society. 2012;134(16):6948-51. doi: 10.1021/ja301621z. PMID: 22475086.

Lee H, Lytton-Jean AK, Chen Y, Love KT, Park AI, Karagiannis ED, Sehgal A, Querbes W, Zurenko CS, Jayaraman M, Peng CG, Charisse K, Borodovsky A, Manoharan M, Donahoe JS, Truelove J, Nahrendorf M, Langer R, Anderson DG. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol. 2012;7(6):389-93. doi: 10.1038/nnano.2012.73. PMCID: PMC3898745.

Fisher OZ, Larson BL, Hill PS, Graupner D, Nguyen-Kim MT, Kehr NS, De Cola L, Langer R, Anderson DG. Melanin-like hydrogels derived from gallic macromers. Advanced Materials. 2012;24(22):3032-6. doi: 10.1002/adma.201104437. NIHMSID#595480

Cho SW, Yang F, Son SM, Park HJ, Green JJ, Bogatyrev S, Mei Y, Park S, Langer R, Anderson DG. Therapeutic angiogenesis using genetically engineered human endothelial cells. Journal of Controlled Release 2012;160(3):515-24. doi: 10.1016/j.jconrel.2012.03.006. PMCID: PMC3372613.

Urbanska AM, Karagiannis ED, Guajardo G, Langer RS, Anderson DG. Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer. Biomaterials. 2012;33(18):4752-61. doi: 10.1016/j.biomaterials.2012.03.023. PMCID: PMC3586541.

Nguyen DN, Mahon KP, Chikh G, Kim P, Chung H, Vicari AP, Love KT, Goldberg M, Chen S, Krieg AM, Chen J, Langer R, Anderson DG. Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Proc Natl Acad Sci U S A. 2012;109(14):E797-803. doi: 10.1073/pnas.1121423109. PMCID: PMC3325698.

Eltoukhy AA, Siegwart DJ, Alabi CA, Rajan JS, Langer R, Anderson DG. Effect of molecular weight of amine end-modified poly(beta-amino ester)s on gene delivery efficiency and toxicity. Biomaterials. 2012;33(13):3594-603. doi: 10.1016/j.biomaterials.2012.01.046.  PMCID: PMC3326358.

Siegwart DJ, Leiendecker M, Langer R, Anderson DG. Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers. Macromolecules. 2012;45(3):1254-61. doi: 10.1021/ma3000219. PMCID: PMC3627424.

Kanasty RL, Whitehead KA, Vegas AJ, Anderson DG. Action and reaction: the biological response to siRNA and its delivery vehicles. Molecular Therapy. 2012;20(3):513-24. doi: 10.1038/mt.2011.294. PMCID: PMC3293611.

Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012;109(7):2491-6. doi: 10.1073/pnas.1113744109. PMCID: PMC3289379.

Hook AL, Chang CY, Yang J, Scurr DJ, Langer R, Anderson DG, Atkinson S, Williams P, Davies MC, Alexander MR. Polymer microarrays for high throughput discovery of biomaterials. Journal of Visualized Experiments. 2012(59):e3636. doi: 10.3791/3636. PMCID: PMC3462568.

Sun S, Wang M, Knupp SA, Soto-Feliciano Y, Hu X, Kaplan DL, Langer R, Anderson DG, Xu Q. Combinatorial library of lipidoids for in vitro DNA delivery. Bioconjugate Chemistry. 2012;23(1):135-40. doi: 10.1021/bc200572w. PMCID: PMC3261308.

Schroeder A, Dahlman JE, Sahay G, Love KT, Jiang S, Eltoukhy AA, Levins CG, Wang Y, Anderson DG. Alkane-modified short polyethyleneimine for siRNA delivery. Journal of Controlled Release. 2012;160(2):172-6. doi: 10.1016/j.jconrel.2011.11.030.  PMCID: PMC3814168.

Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T, Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews Cancer. 2012;12(1):39-50. doi: 10.1038/nrc3180. PMID: 22193407.

Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V. Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells. Molecular Therapy — Nucleic Acids 2012;1:e4. doi: 10.1038/mtna.2011.3. PMCID: PMC3381593.

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2011

O'Sullivan ES, Vegas A, Anderson DG, Weir GC. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocr Rev. 2011;32(6):827-44. doi: 10.1210/er.2010-0026. PMCID: PMC3591674.

Timko BP, Whitehead K, Gao W, Kohane DS, Farokhzad O, Anderson D, Langer R. Advances in Drug Delivery. Annual Review of Materials Research. 2011;41(1):1-20. doi: doi:10.1146/annurev-matsci-062910-100359.

Cheng H, Hill PS, Siegwart DJ, Vacanti N, Lytton-Jean AK, Cho SW, Ye A, Langer R, Anderson DG. A novel family of biodegradable poly(ester amide) elastomers. Advanced Materials. 2011;23(12):H95-100. doi: 10.1002/adma.201003482. PMCID: PMC3893923.

Vuorimaa E, Ketola TM, Green JJ, Hanzlikova M, Lemmetyinen H, Langer R, Anderson DG, Urtti A, Yliperttula M. Poly(beta-amino ester)-DNA complexes: time-resolved fluorescence and cellular transfection studies. Journal of Controlled Release. 2011;154(2):171-6. doi: 10.1016/j.jconrel.2011.06.016. PMCID: PMC3362269.

Dvir T, Bauer M, Schroeder A, Tsui JH, Anderson DG, Langer R, Liao R, Kohane DS. Nanoparticles targeting the infarcted heart. Nano Lett. 2011;11(10):4411-4. doi: 10.1021/nl2025882. PMCID: PMC3192253.

Zoldan J, Lytton-Jean AK, Karagiannis ED, Deiorio-Haggar K, Bellan LM, Langer R, Anderson DG. Directing human embryonic stem cell differentiation by non-viral delivery of siRNA in 3D culture. Biomaterials. 2011;32(31):7793-800. doi: 10.1016/j.biomaterials.2011.06.057. PMCID: PMC3313656.

Hwang NS, Im SG, Wu PB, Bichara DA, Zhao X, Randolph MA, Langer R, Anderson DG. Chondrogenic priming adipose-mesenchymal stem cells for cartilage tissue regeneration. Pharmaceutical Research. 2011;28(6):1395-405. doi: 10.1007/s11095-011-0445-2. PMID: 21494923.

Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011;29(11):1005-10. doi: 10.1038/nbt.1989. PMCID: PMC3212614.

Flessner RM, Jewell CM, Anderson DG, Lynn DM. Degradable polyelectrolyte multilayers that promote the release of siRNA. Langmuir. 2011;27(12):7868-76. doi: 10.1021/la200815t. PMCID: PMC3115451.

Whitehead KA, Dahlman JE, Langer RS, Anderson DG. Silencing or stimulation? siRNA delivery and the immune system. Annu Rev Chem Biomol Eng. 2011;2:77-96. doi: 10.1146/annurev-chembioeng-061010-114133. PMID: 22432611.

Hook AL, Yang J, Chen X, Roberts CJ, Mei Y, Anderson DG, Langer R, Alexander MR, Davies MC. Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray. Soft Matter. 2011;7(16):7194-7. doi: 10.1039/C1SM06063E.  PMCID: PMC3524802.

Saha K, Mei Y, Reisterer CM, Pyzocha NK, Yang J, Muffat J, Davies MC, Alexander MR, Langer R, Anderson DG, Jaenisch R. Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc Natl Acad Sci U S A. 2011;108(46):18714-9. doi: 10.1073/pnas.1114854108. PMCID: PMC3219112.

Lytton-Jean AK, Langer R, Anderson DG. Five years of siRNA delivery: spotlight on gold nanoparticles. Small. 2011;7(14):1932-7. doi: 10.1002/smll.201100761. PMID: 21681985.

Ma M, Liu WF, Hill PS, Bratlie KM, Siegwart DJ, Chin J, Park M, Guerreiro J, Anderson DG. Development of cationic polymer coatings to regulate foreign-body responses. Advanced Materials. 2011;23(24):H189-94. doi: 10.1002/adma.201100513. PMCID: PMC3957182.

Dang TT, Bratlie KM, Bogatyrev SR, Chen XY, Langer R, Anderson DG. Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response. Biomaterials. 2011;32(19):4464-70. doi: 10.1016/j.biomaterials.2011.02.048. PMID: 21429573.

Liu WF, Ma M, Bratlie KM, Dang TT, Langer R, Anderson DG. Real-time in vivo detection of biomaterial-induced reactive oxygen species. Biomaterials. 2011;32(7):1796-801. doi: 10.1016/j.biomaterials.2010.11.029. PMID: 21146868.

Zhou M, Liu H, Venkiteshwaran A, Kilduff J, Anderson DG, Langer R, Belfort G. High throughput discovery of new fouling-resistant surfaces. Journal of Materials Chemistry. 2011;21(3):693-704. doi: 10.1039/C0JM01266A.

Whitehead KA, Sahay G, Li GZ, Love KT, Alabi CA, Ma M, Zurenko C, Querbes W, Langer RS, Anderson DG. Synergistic silencing: combinations of lipid-like materials for efficacious siRNA delivery. Molecular Therapy. 2011;19(9):1688-94. doi: 10.1038/mt.2011.141. PMCID: PMC3182356.

Pritchard CD, O'Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R. An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Biomaterials. 2011;32(2):587-97. doi: 10.1016/j.biomaterials.2010.08.106. PMID: 20880573.

Chung HJ, Lee H, Bae KH, Lee Y, Park J, Cho SW, Hwang JY, Park H, Langer R, Anderson D, Park TG. Facile synthetic route for surface-functionalized magnetic nanoparticles: cell labeling and magnetic resonance imaging studies. ACS Nano. 2011;5(6):4329-36. doi: 10.1021/nn201198f. PMID: 21619063.

Siegwart DJ, Whitehead KA, Nuhn L, Sahay G, Cheng H, Jiang S, Ma M, Lytton-Jean A, Vegas A, Fenton P, Levins CG, Love KT, Lee H, Cortez C, Collins SP, Li YF, Jang J, Querbes W, Zurenko C, Novobrantseva T, Langer R, Anderson DG. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. Proc Natl Acad Sci U S A. 2011;108(32):12996-3001. doi: 10.1073/pnas.1106379108. PMCID: PMC3156157.

Zoldan J, Karagiannis ED, Lee CY, Anderson DG, Langer R, Levenberg S. The influence of scaffold elasticity on germ layer specification of human embryonic stem cells. Biomaterials. 2011;32(36):9612-21. doi: 10.1016/j.biomaterials.2011.09.012.  PMCID: PMC3313669.

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2010

Mei Y, Saha K, Bogatyrev SR, Yang J, Hook AL, Kalcioglu ZI, Cho SW, Mitalipova M, Pyzocha N, Rojas F, Van Vliet KJ, Davies MC, Alexander MR, Langer R, Jaenisch R, Anderson DG. Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater. 2010;9(9):768-78. doi: 10.1038/nmat2812. PMCID: PMC3388774.

De Sousa FB, Guerreiro JDT, Ma M, Anderson DG, Drum CL, Sinisterra RD, Langer R. Photo-response behavior of electrospun nanofibers based on spiropyran-cyclodextrin modified polymer. Journal of Materials Chemistry. 2010;20(44):9910-7. doi: 10.1039/C0JM01903H.

Yang J, Mei Y, Hook AL, Taylor M, Urquhart AJ, Bogatyrev SR, Langer R, Anderson DG, Davies MC, Alexander MR. Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays. Biomaterials. 2010;31(34):8827-38. doi: 10.1016/j.biomaterials.2010.08.028. PMCID: PMC2992358.

Mahon KP, Love KT, Whitehead KA, Qin J, Akinc A, Leshchiner E, Leshchiner I, Langer R, Anderson DG. Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery. Bioconjugate Chemistry. 2010;21(8):1448-54. doi: 10.1021/bc100041r. PMCID: PMC2931596.

Huang YH, Cozzitorto JA, Richards NG, Eltoukhy AA, Yeo CJ, Langer R, Anderson DG, Brody JR, Sawicki JA. CanScript, an 18-Base pair DNA sequence, boosts tumor cell-specific promoter activity: implications for targeted gene therapy. Cancer Biol Ther. 2010;10(9):878-84. doi: 10.4161/cbt.10.9.13234. PMCID: PMC3040857.

Cigler P, Lytton-Jean AK, Anderson DG, Finn MG, Park SY. DNA-controlled assembly of a NaTl lattice structure from gold nanoparticles and protein nanoparticles. Nat Mater. 2010;9(11):918-22. doi: 10.1038/nmat2877. PubMed PMID: 20953184.

Mei Y, Hollister-Lock J, Bogatyrev SR, Cho SW, Weir GC, Langer R, Anderson DG. A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials. 2010;31(34):8989-95. doi: 10.1016/j.biomaterials.2010.08.029. PMCID: PMC3415986.

Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010;11(8):1909-14. doi: 10.1021/bm100357t. PMCID: PMC2946176.

Davies MC, Alexander MR, Hook AL, Yang J, Mei Y, Taylor M, Urquhart AJ, Langer R, Anderson DG. High throughput surface characterization: A review of a new tool for screening prospective biomedical material arrays. J Drug Target. 2010;18(10):741-51. doi: 10.3109/1061186X.2010.521941. PMID: 20945971.

Shmueli RB, Anderson DG, Green JJ. Electrostatic surface modifications to improve gene delivery. Expert Opin Drug Deliv. 2010;7(4):535-50. doi: 10.1517/17425241003603653. PMCID: PMC2911010.

Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG. Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS One. 2010;5(4):e10032. doi: 10.1371/journal.pone.0010032. PMCID: PMC2850367.

Cheng H, Kastrup CJ, Ramanathan R, Siegwart DJ, Ma M, Bogatyrev SR, Xu Q, Whitehead KA, Langer R, Anderson DG. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano. 2010;4(2):625-31. doi: 10.1021/nn901319y. PMCID: PMC2836800.

Hook AL, Anderson DG, Langer R, Williams P, Davies MC, Alexander MR. High throughput methods applied in biomaterial development and discovery. Biomaterials. 2010;31(2):187-98. doi: 10.1016/j.biomaterials.2009.09.037. PMID: 19815273.

Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, Frank-Kamenetsky M, Yip KN, Alvarez R, Sah DW, de Fougerolles A, Fitzgerald K, Koteliansky V, Akinc A, Langer R, Anderson DG. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A. 2010;107(5):1864-9. doi: 10.1073/pnas.0910603106.  PMCID: PMC2804742.

Schroeder A, Levins CG, Cortez C, Langer R, Anderson DG. Lipid-based nanotherapeutics for siRNA delivery. J Intern Med. 2010;267(1):9-21. doi: 10.1111/j.1365-2796.2009.02189.x. PMID: 20059641.

Harris TJ, Green JJ, Fung PW, Langer R, Anderson DG, Bhatia SN. Tissue-specific gene delivery via nanoparticle coating. Biomaterials. 2010;31(5):998-1006. doi: 10.1016/j.biomaterials.2009.10.012. PMCID: PMC2796451.

Yang F, Cho SW, Son SM, Bogatyrev SR, Singh D, Green JJ, Mei Y, Park S, Bhang SH, Kim BS, Langer R, Anderson DG. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A. 2010;107(8):3317-22. doi: 10.1073/pnas.0905432106.  PMCID: PMC2840438.

Zhou M, Liu H, Kilduff JE, Langer R, Anderson DG, Belfort G. High throughput synthesis and screening of new protein resistant surfaces for membrane filtration. AIChE Journal. 2010;56(7):1932-45. doi: 10.1002/aic.12104.

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2009

Stone GW, Barzee S, Snarsky V, Santucci C, Tran B, Langer R, Zugates GT, Anderson DG, Kornbluth RS. Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma. PLoS One. 2009;4(10):e7334. doi: 10.1371/journal.pone.0007334. PMCID: PMC2754331.

Dang TT, Xu Q, Bratlie KM, O'Sullivan ES, Chen XY, Langer R, Anderson DG. Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules. Biomaterials. 2009;30(36):6896-902. doi: 10.1016/j.biomaterials.2009.09.012. PMID: 19800116.

Karagiannis ED, Anderson DG. Minicells overcome tumor drug-resistance. Nat Biotechnol. 2009;27(7):620-1. doi: 10.1038/nbt0709-620. PMID: 19587665.

Lee JS, Green JJ, Love KT, Sunshine J, Langer R, Anderson DG. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 2009;9(6):2402-6. doi: 10.1021/nl9009793. PMCID: PMC2728206.

Nguyen DN, Chen SC, Lu J, Goldberg M, Kim P, Sprague A, Novobrantseva T, Sherman J, Shulga-Morskaya S, de Fougerolles A, Chen J, Langer R, Anderson DG. Drug delivery-mediated control of RNA immunostimulation. Molecular Therapy. 2009;17(9):1555-62. doi: 10.1038/mt.2009.147. PMCID: PMC2835254.

Sunshine J, Green JJ, Mahon KP, Yang F, Eltoukhy AA, Nguyen DN, Langer R, Anderson DG. Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy. Advanced Materials. 2009;21(48):4947-51. doi: 10.1002/adma.200901718.

Cho SW, Goldberg M, Son SM, Xu Q, Yang F, Mei Y, Bogatyrev S, Langer R, Anderson DG. Lipid-like Nanoparticles for Small Interfering RNA Delivery to Endothelial Cells. Adv Funct Mater. 2009;19(19):3112-8. doi: 10.1002/adfm.200900519. PMCID: PMC3564673.

Huang YH, Zugates GT, Peng W, Holtz D, Dunton C, Green JJ, Hossain N, Chernick MR, Padera RF, Jr., Langer R, Anderson DG, Sawicki JA. Nanoparticle-delivered suicide gene therapy effectively reduces ovarian tumor burden in mice. Cancer Res. 2009;69(15):6184-91. doi: 10.1158/0008-5472.CAN-09-0061. PMCID: PMC2735403.

Nguyen DN, Kim P, Martinez-Sobrido L, Beitzel B, Garcia-Sastre A, Langer R, Anderson DG. A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery. Biotechnol Bioeng. 2009;103(4):664-75. doi: 10.1002/bit.22312. PMCID: PMC2771114.

Bhang SH, Cho SW, Lim JM, Kang JM, Lee TJ, Yang HS, Song YS, Park MH, Kim HS, Yoo KJ, Jang Y, Langer R, Anderson DG, Kim BS. Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells. 2009;27(8):1976-86. doi: 10.1002/stem.115. PMID: 19544425.

Zhou M, Liu H, Kilduff JE, Langer R, Anderson DG, Belfort G. High-throughput membrane surface modification to control NOM fouling. Environ Sci Technol. 2009;43(10):3865-71. PMID: 19544900.

Taylor M, Urquhart AJ, Anderson DG, Langer R, Davies MC, Alexander MR. Partial least squares regression as a powerful tool for investigating large combinatorial polymer libraries. Surface and Interface Analysis. 2009;41(2):127-35. doi: 10.1002/sia.2969.

Akinc A, Goldberg M, Qin J, Dorkin JR, Gamba-Vitalo C, Maier M, Jayaprakash KN, Jayaraman M, Rajeev KG, Manoharan M, Koteliansky V, Röhl I, Leshchiner ES, Langer R, Anderson DG. Development of lipidoid-siRNA formulations for systemic delivery to the liver. Molecular Therapy. 2009;17(5):872-9. doi: 10.1038/mt.2009.36. PMCID: PMC2835134.

Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Anderson DG. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009;5(13):1575-81. doi: 10.1002/smll.200801855. PMCID: PMC2789598.

Yang F, Mei Y, Langer R, Anderson DG. High throughput optimization of stem cell microenvironments. Combinatorial Chemistry & High Throughput Screening. 2009;12(6):554-61. PMCID: PMC2748120.

Mei Y, Gerecht S, Taylor M, Urquhart AJ, Bogatyrev SR, Cho S-W, Davies MC, Alexander MR, Langer RS, Anderson DG. Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells. Advanced Materials. 2009;21(27):2781-6. doi: 10.1002/adma.200803184.

Whitehead KA, Langer R, Anderson DG. Knocking down barriers: advances in siRNA delivery. Nature Reviews Drug Discovery. 2009;8(2):129-38.

Nguyen DN, Green JJ, Chan JM, Langer R, Anderson DG. Polymeric Materials for Gene Delivery and DNA Vaccination. Advanced Materials. 2009;21(8):847-67. doi: 10.1002/adma.200801478.

Yang F, Green JJ, Dinio T, Keung L, Cho SW, Park H, Langer R, Anderson DG. Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors. Gene Ther. 2009;16(4):533-46. doi: 10.1038/gt.2008.182. PMCID: PMC2688702.

Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci U S A. 2009;106(9):3426-30. doi: 10.1073/pnas.0813348106. PMCID: PMC2651300.

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2008

Cho SW, Hartle L, Son SM, Yang F, Goldberg M, Xu Q, Langer R, Anderson DG. Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. Biochem Biophys Res Commun. 2008;376(1):158-63. doi: 10.1016/j.bbrc.2008.08.123. PMID: 18765230.

Svensson RU, Shey MR, Ballas ZK, Dorkin JR, Goldberg M, Akinc A, Langer R, Anderson DG, Bumcrot D, Henry MD. Assessing siRNA pharmacodynamics in a luciferase-expressing mouse. Molecular Therapy. 2008;16(12):1995-2001. doi: 10.1038/mt.2008.187.

Showalter SL, Huang YH, Witkiewicz A, Costantino CL, Yeo CJ, Green JJ, Langer R, Anderson DG, Sawicki JA, Brody JR. Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells. Cancer Biol Ther. 2008;7(10):1584-90. PMCID: PMC3218426.

Mei Y, Cannizzaro C, Park H, Xu Q, Bogatyrev SR, Yi K, Goldman N, Langer R, Anderson DG. Cell-compatible, multicomponent protein arrays with subcellular feature resolution. Small. 2008;4(10):1600-4. doi: 10.1002/smll.200800363. PMCID: PMC2679812.

Green JJ, Zhou BY, Mitalipova MM, Beard C, Langer R, Jaenisch R, Anderson DG. Nanoparticles for gene transfer to human embryonic stem cell colonies. Nano Lett. 2008;8(10):3126-30. doi: 10.1021/nl8012665. PMCID: PMC3814161.

Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, Gamba-Vitalo C, Hadwiger P, Jayaraman M, John M, Jayaprakash KN, Maier M, Nechev L, Rajeev KG, Read T, Rohl I, Soutschek J, Tan P, Wong J, Wang G, Zimmermann T, de Fougerolles A, Vornlocher HP, Langer R, Anderson DG, Manoharan M, Koteliansky V, Horton JD, Fitzgerald K. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A. 2008;105(33):11915-20. doi: 10.1073/pnas.0805434105. PMCID: PMC2575310.

Taylor M, Urquhart AJ, Anderson DG, Williams PM, Langer R, Alexander MR, Davies MC. A Methodology for Investigating Protein Adhesion and Adsorption to Microarrayed Combinatorial Polymers. Macromolecular Rapid Communications. 2008;29(15):1298-302. doi: 10.1002/marc.200800171.

Epiphanio S, Mikolajczak SA, Goncalves LA, Pamplona A, Portugal S, Albuquerque S, Goldberg M, Rebelo S, Anderson DG, Akinc A, Vornlocher HP, Kappe SH, Soares MP, Mota MM. Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection. Cell Host Microbe. 2008;3(5):331-8. doi: 10.1016/j.chom.2008.04.003. PMID: 18474360.

Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, Narayanannair Jayaprakash K, Jayaraman M, John M, Koteliansky V, Manoharan M, Nechev L, Qin J, Racie T, Raitcheva D, Rajeev KG, Sah DW, Soutschek J, Toudjarska I, Vornlocher HP, Zimmermann TS, Langer R, Anderson DG. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol. 2008;26(5):561-9. doi: 10.1038/nbt1402. PMCID: PMC3014085.

Goldberg M, Mahon K, Anderson D. Combinatorial and rational approaches to polymer synthesis for medicine. Adv Drug Deliv Rev. 2008;60(9):971-8. doi: 10.1016/j.addr.2008.02.005. PMCID: PMC2536566.

Karnik R, Hong S, Zhang H, Mei Y, Anderson DG, Karp JM, Langer R. Nanomechanical control of cell rolling in two dimensions through surface patterning of receptors. Nano Lett. 2008;8(4):1153-8. doi: 10.1021/nl073322a. PMCID: PMC2911031.

Green JJ, Langer R, Anderson DG. A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res. 2008;41(6):749-59. doi: 10.1021/ar7002336. PMCID: PMC3490629.

Urquhart AJ, Taylor M, Anderson DG, Langer R, Davies MC, Alexander MR. TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettability. Anal Chem. 2008;80(1):135-42. doi: 10.1021/ac071560k. PMID: 18044847.

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2007

Zugates GT, Tedford NC, Zumbuehl A, Jhunjhunwala S, Kang CS, Griffith LG, Lauffenburger DA, Langer R, Anderson DG. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjugate Chemistry. 2007;18(6):1887-96. doi: 10.1021/bc7002082. PMID: 17929884.

John M, Constien R, Akinc A, Goldberg M, Moon YA, Spranger M, Hadwiger P, Soutschek J, Vornlocher HP, Manoharan M, Stoffel M, Langer R, Anderson DG, Horton JD, Koteliansky V, Bumcrot D. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature. 2007;449(7163):745-7. doi: 10.1038/nature06179.  PMCID: PMC3019095.

Urquhart AJ, Anderson DG, Taylor M, Alexander MR, Langer R, Davies MC. High Throughput Surface Characterisation of a Combinatorial Material Library. Advanced Materials. 2007;19(18):2486-91. doi: 10.1002/adma.200700949.

Green JJ, Zugates GT, Tedford NC, Huang YH, Griffith LG, Lauffenburger DA, Sawicki JA, Langer R, Anderson DG. Combinatorial Modification of Degradable Polymers Enables Transfection of Human Cells Comparable to Adenovirus. Advanced Materials. 2007;19(19):2836-42. doi: 10.1002/adma.200700371.

Mei Y, Goldberg M, Anderson D. The development of high-throughput screening approaches for stem cell engineering. Curr Opin Chem Biol. 2007;11(4):388-93. doi: 10.1016/j.cbpa.2007.07.006.  PMCID: PMC3017753.

Zugates GT, Peng W, Zumbuehl A, Jhunjhunwala S, Huang YH, Langer R, Sawicki JA, Anderson DG. Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s. Molecular Therapy. 2007;15(7):1306-12. doi: 10.1038/mt.sj.6300132. PMID: 17375071.

Green JJ, Chiu E, Leshchiner ES, Shi J, Langer R, Anderson DG. Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells. Nano Lett. 2007;7(4):874-9. doi: 10.1021/nl062395b. PMID: 17362046.

Peng W, Anderson DG, Bao Y, Padera RF, Jr., Langer R, Sawicki JA. Nanoparticulate delivery of suicide DNA to murine prostate and prostate tumors. Prostate. 2007;67(8):855-62. Epub 2007/04/12. doi: 10.1002/pros.20576. PMID: 17427200.

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2006

Green JJ, Shi J, Chiu E, Leshchiner ES, Langer R, Anderson DG. Biodegradable polymeric vectors for gene delivery to human endothelial cells. Bioconjugate Chemistry. 2006;17(5):1162-9. Epub 2006/09/21. doi: 10.1021/bc0600968. PMID: 16984124.

Zugates GT, Anderson DG, Little SR, Lawhorn IE, Langer R. Synthesis of poly(beta-amino ester)s with thiol-reactive side chains for DNA delivery. Journal of the American Chemical Society. 2006;128(39):12726-34. Epub 2006/09/28. doi: 10.1021/ja061570n. PMID: 17002366.

Anderson DG, Tweedie CA, Hossain N, Navarro SM, Brey DM, Van Vliet KJ, Langer R, Burdick JA. A Combinatorial Library of Photocrosslinkable and Degradable Materials. Advanced Materials. 2006;18(19):2614-8. doi: 10.1002/adma.200600529.

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2005

Tweedie CA, Anderson DG, Langer R, Van Vliet KJ. Combinatorial Material Mechanics: High-Throughput Polymer Synthesis and Nanomechanical Screening. Advanced Materials. 2005;17(21):2599-604. doi: 10.1002/adma.200501142.

Zugates GT, Little SR, Anderson DG, Langer R. Poly(ß-amino ester)s for DNA delivery. Israel Journal of Chemistry. 2005;45(4):477-85. doi: 10.1560/7C67-5X19-PEJ8-PXUN.

Stevens MM, Mayer M, Anderson DG, Weibel DB, Whitesides GM, Langer R. Direct patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps. Biomaterials. 2005;26(36):7636-41. doi: 10.1016/j.biomaterials.2005.05.001. PMID: 15979701.

Greenland JR, Liu H, Berry D, Anderson DG, Kim WK, Irvine DJ, Langer R, Letvin NL. Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Molecular Therapy. 2005;12(1):164-70. doi: 10.1016/j.ymthe.2005.01.021. PMID: 15963932.

Anderson DG, Akinc A, Hossain N, Langer R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Molecular Therapy. 2005;11(3):426-34. Epub 2005/02/25. doi: 10.1016/j.ymthe.2004.11.015. PMID: 15727939.

Anderson DG, Putnam D, Lavik EB, Mahmood TA, Langer R. Biomaterial microarrays: rapid, microscale screening of polymer-cell interaction. Biomaterials. 2005;26(23):4892-7. doi: 10.1016/j.biomaterials.2004.11.052. PMID: 15763269.

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2004

Anderson DG, Peng W, Akinc A, Hossain N, Kohn A, Padera R, Langer R, Sawicki JA. A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sci U S A. 2004;101(45):16028-33. doi: 10.1073/pnas.0407218101. PMCID: PMC528737.

Anderson DG, Levenberg S, Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol. 2004;22(7):863-6. doi: 10.1038/nbt981. PMID: 15195101.

Anderson DG, Burdick JA, Langer R. Materials science. Smart biomaterials. Science. 2004;305(5692):1923-4. doi: 10.1126/science.1099987. PMID: 15448260.

Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS. pH-triggered microparticles for peptide vaccination. J Immunol. 2004;173(4):2578-85. PMID: 15294974.

Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004;101(26):9534-9. doi: 10.1073/pnas.0403549101. PMCID: PMC470709.

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2003

Kohane DS, Anderson DG, Yu C, Langer R. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharmaceutical Research. 2003;20(10):1533-8. PMID: 14620503.

Jon S, Anderson DG, Langer R. Degradable poly(amino alcohol esters) as potential DNA vectors with low cytotoxicity. Biomacromolecules. 2003;4(6):1759-62. doi: 10.1021/bm034176f. PMID: 14606906.

Akinc A, Anderson DG, Lynn DM, Langer R. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjugate Chemistry. 2003;14(5):979-88. doi: 10.1021/bc034067y. PMID: 13129402.

Anderson DG, Lynn DM, Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl. 2003;42(27):3153-8. doi: 10.1002/anie.200351244. PMID: 12866105.

Akinc A, Lynn DM, Anderson DG, Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. Journal of the American Chemical Society. 2003;125(18):5316-23. doi: 10.1021/ja034429c. PMID: 12720443.

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2001

Lynn DM, Anderson DG, Putnam D, Langer R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. Journal of the American Chemical Society. 2001;123(33):8155-6. PMID: 11506588.

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1999

Churchill JJ, Anderson DG, Kowalczykowski SC. The RecBC enzyme loads RecA protein onto ssDNA asymmetrically and independently of chi, resulting in constitutive recombination activation. Genes and Development. 1999;13(7):901-11. PMCID: PMC316600.

Anderson DG, Churchill JJ, Kowalczykowski SC. A single mutation, RecB(D1080A,) eliminates RecA protein loading but not Chi recognition by RecBCD enzyme. Journal of Biological Chemistry. 1999;274(38):27139-44. PMID: 10480929.

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1998

Anderson DG, Kowalczykowski SC. SSB protein controls RecBCD enzyme nuclease activity during unwinding: a new role for looped intermediates. Journal of Molecular Biology. 1998;282(2):275-85. doi: 10.1006/jmbi.1998.2013. PMID: 9735287.

Anderson DG, Kowalczykowski SC. Reconstitution of an SOS response pathway: derepression of transcription in response to DNA breaks. Cell. 1998;95(7):975-9. PMID: 9875851.

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1997

Anderson DG, Churchill JJ, Kowalczykowski SC. Chi-activated RecBCD enzyme possesses 5'-->3' nucleolytic activity, but RecBC enzyme does not: evidence suggesting that the alteration induced by Chi is not simply ejection of the RecD subunit. Genes to Cells. 1997;2(2):117-28. PMID: 9167969.

Anderson DG, Kowalczykowski SC. The recombination hot spot chi is a regulatory element that switches the polarity of DNA degradation by the RecBCD enzyme. Genes and Development. 1997;11(5):571-81. PMID: 9119222.

Anderson DG, Kowalczykowski SC. The translocating RecBCD enzyme stimulates recombination by directing RecA protein onto ssDNA in a chi-regulated manner. Cell. 1997;90(1):77-86. PMID: 9230304.